Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ABL1 | P00519 | 5/20 | 0.53 |
| ▸ | ABCB1 | P08183 | 5/20 | 0.53 |
| ▸ | BCR | P11274 | 5/20 | 0.53 |
| ▸ | CYP1A1 | P04798 | 3/20 | 0.46 |
| ▸ | CYP1B1 | Q16678 | 3/20 | 0.46 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.46 |
| ▸ | CYP2E1 | P05181 | 2/20 | 0.46 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.46 |
| ▸ | CYP2C8 | P10632 | 2/20 | 0.46 |
| ▸ | CYP2D6 | P10635 | 2/20 | 0.46 |
| ▸ | CYP2A6 | P11509 | 2/20 | 0.46 |
| ▸ | CYP2C9 | P11712 | 2/20 | 0.46 |
| ▸ | CYP4B1 | P13584 | 2/20 | 0.46 |
| ▸ | CYP2B6 | P20813 | 2/20 | 0.46 |
| ▸ | CYP3A5 | P20815 | 2/20 | 0.46 |
| ▸ | CYP2A7 | P20853 | 2/20 | 0.46 |
| ▸ | CYP3A7 | P24462 | 2/20 | 0.46 |
| ▸ | CYP2F1 | P24903 | 2/20 | 0.46 |
| ▸ | CYP2C18 | P33260 | 2/20 | 0.46 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7839215 | 0.86 | CYP1A1 (0.45) | CYP1A1CYP1B1CYP1A2CYP2E1CYP3A4 | |
| SCHEMBL4561266 | 0.84 | ABL1 (0.50) | ABL1ABCB1BCRTP53TSHR | |
| SCHEMBL9330420 | 0.82 | ABL1 (0.53) | ABL1ABCB1BCRCYP1A1CYP1B1 | |
| SCHEMBL17514627 | 0.81 | ABL1 (0.56) | ABL1ABCB1BCRCYP1A1CYP1B1 | |
| SCHEMBL17514701 | 0.81 | ABL1 (0.51) | ABL1ABCB1BCRCYP1A1CYP1B1 | |
| SCHEMBL6951096 | 0.77 | ABL1 (0.47) | ABL1ABCB1BCRCYP1A1CYP1B1 | |
| SCHEMBL2013153 | 0.76 | HTR1A (0.35) | — | |
| SCHEMBL1583993 | 0.73 | RAB9A (0.40) | CYP1A2CYP3A4CYP2D6CYP2A6CYP2C9 | |
| SCHEMBL22115865 | 0.73 | — | — | |
| SCHEMBL695988 | 0.72 | PDCD1 (0.39) | CYP2A6CYP2B6ALDH1A1TSHRKMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1615890-A1 | PIPERIDINE DERIVATIVES AS RENIN INHIBITORS FOR THE TREATMENT OF HYPERTENSION | WARNER-LAMBERT COMPANY (US) | 2006-01-18 | — | — | EP | disclosed |
| WO-2004089903-A1 | PIPERIDINE DERIVATIVES AS RENIN INHIBITORS FOR THE TREATMENT OF HYPERTENSION | WARNER-LAMBERT COMPANY LLC (US) | 2004-10-21 | — | — | WO | disclosed |