Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KEAP1 | Q14145 | 1/20 | 0.41 |
| ▸ | NFE2L2 | Q16236 | 1/20 | 0.41 |
| ▸ | LMNA | P02545 | 2/20 | 0.38 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.35 |
| ▸ | MEN1 | O00255 | 3/20 | 0.35 |
| ▸ | CRHBP | P24387 | 1/20 | 0.35 |
| ▸ | CRHR2 | Q13324 | 1/20 | 0.35 |
| ▸ | HPGD | P15428 | 3/20 | 0.34 |
| ▸ | HAVCR2 | Q8TDQ0 | 1/20 | 0.33 |
| ▸ | GABRP | O00591 | 2/20 | 0.33 |
| ▸ | GABRD | O14764 | 2/20 | 0.33 |
| ▸ | GABRA1 | P14867 | 2/20 | 0.33 |
| ▸ | GABRB1 | P18505 | 2/20 | 0.33 |
| ▸ | GABRG2 | P18507 | 2/20 | 0.33 |
| ▸ | GABRB3 | P28472 | 2/20 | 0.33 |
| ▸ | GABRA5 | P31644 | 2/20 | 0.33 |
| ▸ | GABRA3 | P34903 | 2/20 | 0.33 |
| ▸ | GABRA2 | P47869 | 2/20 | 0.33 |
| ▸ | GABRB2 | P47870 | 2/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL721758 | 0.75 | KEAP1 (0.47) | KEAP1NFE2L2LMNASMN1; SMN2KMT2A | |
| Hydrochloric Acid SCHEMBL7754141 | 0.73 | KEAP1 (0.46) | KEAP1NFE2L2LMNASMN1; SMN2KMT2A | |
| SCHEMBL14637332 | 0.73 | KEAP1 (0.46) | KEAP1NFE2L2LMNASMN1; SMN2KMT2A | |
| SCHEMBL8738488 | 0.73 | KEAP1 (0.46) | KEAP1NFE2L2LMNASMN1; SMN2KMT2A | |
| SCHEMBL4274478 | 0.72 | HPGD (0.44) | KEAP1NFE2L2LMNASMN1; SMN2KMT2A | |
| Ethylene SCHEMBL29153723 | 0.72 | NFKB1 (0.44) | KEAP1NFE2L2LMNASMN1; SMN2KMT2A | |
| Hydrochloric Acid SCHEMBL10585295 | 0.70 | HPGD (0.43) | KEAP1NFE2L2LMNASMN1; SMN2KMT2A | |
| SCHEMBL8725907 | 0.69 | ALDH1A1 (0.47) | LMNAHPGDGABRPGABRDGABRA1 | |
| SCHEMBL3974375 | 0.69 | SMN1; SMN2 (0.45) | KEAP1NFE2L2LMNASMN1; SMN2KMT2A | |
| Dimethylformamide SCHEMBL27816337 | 0.68 | HPGD (0.41) | KEAP1NFE2L2LMNASMN1; SMN2KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1682532-A1 | PYRIMIDINES AS INHIBITORS OF PHOSPHOINOSITIDE-3-KINASES (PI3K) | Warner-Lambert Company LLC (US) | 2006-07-26 | — | — | EP | disclosed |
| WO-2005042519-A1 | PYRIMIDINES AS INHIBITORS OF PHOSPHOINOSITIDE -3-KINASES (PI3K) | WARNER-LAMBERT COMPANY LLC (US) | 2005-05-12 | — | — | WO | disclosed |