Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CHRNB2 | P17787 | 1/20 | 0.54 |
| ▸ | CHRNA4 | P43681 | 1/20 | 0.54 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.51 |
| ▸ | THRB | P10828 | 1/20 | 0.51 |
| ▸ | HPGD | P15428 | 1/20 | 0.51 |
| ▸ | MEN1 | O00255 | 1/20 | 0.50 |
| ▸ | POLB | P06746 | 1/20 | 0.50 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.50 |
| ▸ | TSHR | P16473 | 2/20 | 0.47 |
| ▸ | MAPT | P10636 | 2/20 | 0.47 |
| ▸ | CTDSP1 | Q9GZU7 | 1/20 | 0.47 |
| ▸ | NPC1 | O15118 | 1/20 | 0.47 |
| ▸ | RAB9A | P51151 | 1/20 | 0.47 |
| ▸ | LMNA | P02545 | 1/20 | 0.47 |
| ▸ | MAOB | P27338 | 1/20 | 0.47 |
| ▸ | HGFAC | Q04756 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL30023557 | 0.86 | CHRNB2 (0.55) | CHRNB2CHRNA4ALDH1A1THRBHPGD | |
| SCHEMBL657597 | 0.86 | CHRNB2 (0.55) | CHRNB2CHRNA4ALDH1A1THRBHPGD | |
| SCHEMBL217722 | 0.81 | LMNA (0.57) | CHRNB2CHRNA4ALDH1A1THRBHPGD | |
| SCHEMBL30601989 | 0.80 | CHRNB2 (0.55) | CHRNB2CHRNA4ALDH1A1THRBHPGD | |
| SCHEMBL27468480 | 0.80 | CHRNB2 (0.55) | CHRNB2CHRNA4ALDH1A1THRBHPGD | |
| SCHEMBL10753064 | 0.80 | CHRNB2 (0.58) | CHRNB2CHRNA4ALDH1A1THRBHPGD | |
| SCHEMBL7939211 | 0.80 | CHRNB2 (0.55) | CHRNB2CHRNA4ALDH1A1THRBHPGD | |
| SCHEMBL10041787 | 0.79 | CHRNB2 (0.60) | CHRNB2CHRNA4ALDH1A1MEN1POLB | |
| SCHEMBL15498199 | 0.79 | CHRNB2 (0.73) | CHRNB2CHRNA4ALDH1A1HPGDMEN1 | |
| SCHEMBL16178929 | 0.79 | CHRNB2 (0.64) | CHRNB2CHRNA4ALDH1A1TSHRMAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1652839-A2 | Drug efflux pump inhibitor | DAIICHI PHARMACEUTICAL CO., LTD. (JP) | 2006-05-03 | — | — | EP | disclosed |
| EP-1227084-B1 | DRUG DISCHARGE PUMP INHIBITORS | TRINE PHARMACEUTICALS INC (US) | 2005-12-14 | — | — | EP | disclosed |
| CN-1414951-A | Drug discharge pump inhibitor | FUNDAMENTAL THERAPEUTICAL INC (US) | 2003-04-30 | — | — | CN | disclosed |
| EP-1227084-A1 | DRUG DISCHARGE PUMP INHIBITORS | Microcide Pharmaceuticals, Inc. (US) | 2002-07-31 | — | — | EP | disclosed |