Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PTGES | O14684 | 1/20 | 0.48 |
| ▸ | ALOX5 | P09917 | 1/20 | 0.48 |
| ▸ | KDM4E | B2RXH2 | 5/20 | 0.48 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.48 |
| ▸ | SLC26A6 | Q9BXS9 | 1/20 | 0.47 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.47 |
| ▸ | KDM4C | Q9H3R0 | 1/20 | 0.45 |
| ▸ | KDM5B | Q9UGL1 | 1/20 | 0.45 |
| ▸ | MAPT | P10636 | 3/20 | 0.44 |
| ▸ | HPGD | P15428 | 2/20 | 0.44 |
| ▸ | LMNA | P02545 | 1/20 | 0.44 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.44 |
| ▸ | POLB | P06746 | 1/20 | 0.43 |
| ▸ | MMP1 | P03956 | 2/20 | 0.43 |
| ▸ | MMP2 | P08253 | 2/20 | 0.43 |
| ▸ | MMP9 | P14780 | 2/20 | 0.43 |
| ▸ | MMP12 | P39900 | 2/20 | 0.43 |
| ▸ | TP53 | P04637 | 2/20 | 0.43 |
| ▸ | MTNR1A | P48039 | 1/20 | 0.42 |
| ▸ | MTNR1B | P49286 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5820787 | 0.84 | PDE3B (0.42) | ALDH1A1SMN1; SMN2MAPTPDE3BPDE3A | |
| SCHEMBL5779014 | 0.84 | PDE3B (0.49) | PTGESALOX5KDM4ESLC26A6SMN1; SMN2 | |
| SCHEMBL5778710 | 0.83 | SMN1; SMN2 (0.52) | KDM4EALDH1A1SMN1; SMN2MAPTTDP1 | |
| SCHEMBL5055900 | 0.82 | KDM4E (0.48) | KDM4EALDH1A1SMN1; SMN2MAPTHPGD | |
| SCHEMBL5820742 | 0.81 | KDM4E (0.44) | KDM4EALDH1A1SMN1; SMN2MAPTPOLB | |
| SCHEMBL16974053 | 0.78 | KDM4E (0.58) | KDM4EALDH1A1SMN1; SMN2MAPTHPGD | |
| SCHEMBL5744663 | 0.77 | DPP4 (0.65) | KDM4EALDH1A1SMN1; SMN2MAPTHPGD | |
| SCHEMBL22272865 | 0.77 | PTGES (0.53) | PTGESALOX5KDM4EALDH1A1SLC26A6 | |
| SCHEMBL4717597 | 0.77 | ALDH1A1 (0.52) | KDM4EALDH1A1SMN1; SMN2MAPTHPGD | |
| SCHEMBL13494052 | 0.76 | ALDH1A1 (0.49) | PTGESALOX5KDM4EALDH1A1SLC26A6 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1678181-A2 | A2B ADENOSINE RECEPTOR ANTAGONISTS | CV THERAPEUTICS, INC. (US) | 2006-07-12 | — | — | EP | disclosed |
| WO-2005042534-A2 | A2B ADENOSINE RECEPTOR ANTAGONISTS | CV THERAPEUTICS, INC. (US) | 2005-05-12 | — | — | WO | disclosed |