Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE3B | Q13370 | 3/20 | 0.49 |
| ▸ | PDE3A | Q14432 | 3/20 | 0.49 |
| ▸ | PTGES | O14684 | 1/20 | 0.47 |
| ▸ | ALOX5 | P09917 | 1/20 | 0.47 |
| ▸ | JAK2 | O60674 | 1/20 | 0.47 |
| ▸ | JAK3 | P52333 | 1/20 | 0.47 |
| ▸ | SLC26A6 | Q9BXS9 | 1/20 | 0.46 |
| ▸ | POLB | P06746 | 1/20 | 0.45 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.45 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.45 |
| ▸ | TRPM8 | Q7Z2W7 | 1/20 | 0.44 |
| ▸ | TSHR | P16473 | 2/20 | 0.43 |
| ▸ | HCAR2 | Q8TDS4 | 1/20 | 0.43 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.43 |
| ▸ | GAA | P10253 | 1/20 | 0.43 |
| ▸ | STAT1 | P42224 | 1/20 | 0.43 |
| ▸ | RAB9A | P51151 | 1/20 | 0.43 |
| ▸ | GABRA1 | P14867 | 1/20 | 0.42 |
| ▸ | GABRB1 | P18505 | 1/20 | 0.42 |
| ▸ | GABRA3 | P34903 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5055900 | 0.86 | KDM4E (0.48) | SMN1; SMN2TDP1KDM4EGAAMAPT | |
| SCHEMBL5820787 | 0.85 | PDE3B (0.42) | PDE3BPDE3AJAK2JAK3SMN1; SMN2 | |
| SCHEMBL5778710 | 0.84 | SMN1; SMN2 (0.52) | PDE3BPDE3APOLBSMN1; SMN2TDP1 | |
| SCHEMBL5779020 | 0.84 | PTGES (0.48) | PDE3BPDE3APTGESALOX5SLC26A6 | |
| SCHEMBL6856480 | 0.83 | HCAR2 (0.54) | HCAR2 | |
| SCHEMBL5820742 | 0.82 | KDM4E (0.44) | PDE3BPDE3APOLBSMN1; SMN2TSHR | |
| SCHEMBL29026435 | 0.78 | MAPT (0.49) | ALOX5SMN1; SMN2KDM4ERAB9AMAPT | |
| SCHEMBL5779565 | 0.78 | L3MBTL1 (0.48) | PDE3BPDE3AJAK2JAK3SLC26A6 | |
| SCHEMBL15957045 | 0.76 | PTGES (0.53) | PDE3BPDE3APTGESALOX5JAK2 | |
| SCHEMBL30091541 | 0.76 | PTGES (0.53) | PDE3BPDE3APTGESALOX5JAK2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1678181-A2 | A2B ADENOSINE RECEPTOR ANTAGONISTS | CV THERAPEUTICS, INC. (US) | 2006-07-12 | — | — | EP | disclosed |
| WO-2005042534-A2 | A2B ADENOSINE RECEPTOR ANTAGONISTS | CV THERAPEUTICS, INC. (US) | 2005-05-12 | — | — | WO | disclosed |