Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 3/20 | 0.56 |
| ▸ | MAPT | P10636 | 3/20 | 0.54 |
| ▸ | PKM | P14618 | 1/20 | 0.54 |
| ▸ | RAB9A | P51151 | 1/20 | 0.54 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.53 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.53 |
| ▸ | GRM5 | P41594 | 1/20 | 0.49 |
| ▸ | CHRNB2 | P17787 | 1/20 | 0.49 |
| ▸ | CHRNA4 | P43681 | 1/20 | 0.49 |
| ▸ | MAOB | P27338 | 3/20 | 0.46 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.46 |
| ▸ | MEN1 | O00255 | 1/20 | 0.45 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.45 |
| ▸ | CHRNB4 | P30926 | 1/20 | 0.43 |
| ▸ | CHRNA3 | P32297 | 1/20 | 0.43 |
| ▸ | MAOA | P21397 | 2/20 | 0.42 |
| ▸ | HPGD | P15428 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8288267 | 0.86 | GRM5 (0.61) | LMNAMAPTPKMRAB9ASMN1; SMN2 | |
| SCHEMBL14988594 | 0.78 | TLR4 (0.63) | LMNAMAPTPKMRAB9ASMN1; SMN2 | |
| SCHEMBL9721944 | 0.78 | LMNA (0.56) | LMNAMAPTPKMRAB9ASMN1; SMN2 | |
| SCHEMBL5779125 | 0.76 | CYSLTR1 (0.62) | LMNAMAPTSMN1; SMN2RXFP1 | |
| SCHEMBL19175217 | 0.75 | MAOB (0.56) | LMNAMAPTRAB9ASMN1; SMN2CHRNB2 | |
| SCHEMBL27588139 | 0.74 | CHRNB2 (0.45) | LMNAMAPTPKMRAB9ASMN1; SMN2 | |
| SCHEMBL4631758 | 0.74 | CHRNB2 (0.60) | LMNAMAPTGRM5CHRNB2CHRNA4 | |
| SCHEMBL8170687 | 0.73 | MAPT (0.51) | LMNAMAPTPKMRAB9ASMN1; SMN2 | |
| SCHEMBL28057927 | 0.73 | MAPT (0.53) | LMNAMAPTPKMRAB9ASMN1; SMN2 | |
| SCHEMBL12746091 | 0.72 | CHRNB2 (0.62) | LMNAMAPTGRM5CHRNB2CHRNA4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1652839-A2 | Drug efflux pump inhibitor | DAIICHI PHARMACEUTICAL CO., LTD. (JP) | 2006-05-03 | — | — | EP | disclosed |
| EP-1227084-B1 | DRUG DISCHARGE PUMP INHIBITORS | TRINE PHARMACEUTICALS INC (US) | 2005-12-14 | — | — | EP | disclosed |
| EP-1227084-A1 | DRUG DISCHARGE PUMP INHIBITORS | Microcide Pharmaceuticals, Inc. (US) | 2002-07-31 | — | — | EP | disclosed |