Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NPC1 | O15118 | 3/20 | 0.39 |
| ▸ | GABRP | O00591 | 1/20 | 0.38 |
| ▸ | GABRD | O14764 | 1/20 | 0.38 |
| ▸ | GABRA1 | P14867 | 1/20 | 0.38 |
| ▸ | GABRB1 | P18505 | 1/20 | 0.38 |
| ▸ | GABRG2 | P18507 | 1/20 | 0.38 |
| ▸ | GABRB3 | P28472 | 1/20 | 0.38 |
| ▸ | GABRA5 | P31644 | 1/20 | 0.38 |
| ▸ | GABRA3 | P34903 | 1/20 | 0.38 |
| ▸ | GABRA2 | P47869 | 1/20 | 0.38 |
| ▸ | GABRB2 | P47870 | 1/20 | 0.38 |
| ▸ | GABRA4 | P48169 | 1/20 | 0.38 |
| ▸ | GABRE | P78334 | 1/20 | 0.38 |
| ▸ | GABRA6 | Q16445 | 1/20 | 0.38 |
| ▸ | GABRG1 | Q8N1C3 | 1/20 | 0.38 |
| ▸ | GABRG3 | Q99928 | 1/20 | 0.38 |
| ▸ | GABRQ | Q9UN88 | 1/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.34 |
| ▸ | RAB9A | P51151 | 2/20 | 0.34 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20679621 | 0.80 | NPC1 (0.37) | NPC1GABRPGABRDGABRA1GABRB1 | |
| SCHEMBL8264532 | 0.80 | ALDH1A1 (0.55) | NPC1GABRPGABRDGABRA1GABRB1 | |
| SCHEMBL30675604 | 0.80 | NPC1 (0.37) | NPC1GABRPGABRDGABRA1GABRB1 | |
| SCHEMBL24549495 | 0.77 | HSD17B10 (0.40) | NPC1ALDH1A1RAB9AKDM4EHTT | |
| SCHEMBL23994506 | 0.76 | HSD17B10 (0.54) | NPC1GABRPGABRDGABRA1GABRB1 | |
| SCHEMBL9693837 | 0.73 | NPC1 (0.64) | NPC1ALDH1A1RAB9AKDM4EHTT | |
| SCHEMBL3425380 | 0.73 | GABRP (0.38) | NPC1GABRPGABRDGABRA1GABRB1 | |
| SCHEMBL21541889 | 0.72 | MAPKAPK2 (0.47) | NPC1GABRPGABRDGABRA1GABRB1 | |
| SCHEMBL10612037 | 0.71 | NPC1 (0.34) | NPC1ALDH1A1RAB9AKDM4EHPGD | |
| SCHEMBL577623 | 0.71 | GAA (0.57) | NPC1RAB9AHTTGAA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1472254-A4 | PURINE AND ISOSTERIC ANTIBACTERIAL COMPOUNDS | GLSYNTHESIS INC (US) | 2006-02-15 | — | — | EP | disclosed |
| US-6926763-B2 | Purine and isosteric antibacterial compounds | GLSYNTHESIS, INC. (US) | 2005-08-09 | — | — | US | disclosed |
| EP-1472254-A2 | PURINE AND ISOSTERIC ANTIBACTERIAL COMPOUNDS | Glsynthesis Inc. (US) | 2004-11-03 | — | — | EP | disclosed |
| US-20040014773-A1 | Purine and isosteric antibacterial compounds | ACURX PHARMACEUTICALS, LLC | 2004-01-22 | — | — | US | disclosed |
| WO-2003066586-A2 | PURINE AND ISOSTERIC ANTIBACTERIAL COMPOUNDS | GLSYNTHESIS INC. (US) | 2003-08-14 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20040014773-A1 | Purine and isosteric antibacterial compounds | MTAP, AMPD3, MPG | NPC1 3082/4885GABRP 2360/4885GABRD 3012/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.