SCHEMBL577623

SCHEMBL577623

Clc1nc2cc(Cl)c(Cl)cc2[nH]1

nearest known ligand 0.63

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
GAA P10253 1/20 0.57
HTT P42858 1/20 0.57
RHEB Q15382 2/20 0.52
GRIN2D O15399 1/20 0.50
GRIN3B O60391 1/20 0.50
LMNA P02545 1/20 0.50
GRIK1 P39086 1/20 0.50
GRIA1 P42261 1/20 0.50
GRIA2 P42262 1/20 0.50
GRIA3 P42263 1/20 0.50
GRIA4 P48058 1/20 0.50
GRIN1 Q05586 1/20 0.50
GRIN2A Q12879 1/20 0.50
GRIK2 Q13002 1/20 0.50
GRIK3 Q13003 1/20 0.50
GRIN2B Q13224 1/20 0.50
GRIN2C Q14957 1/20 0.50
GRIK4 Q16099 1/20 0.50
GRIK5 Q16478 1/20 0.50
GRIN3A Q8TCU5 1/20 0.50

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL1193135 0.83 MAPT (0.52) GAAHTTRHEBGRIN2DGRIN3B
SCHEMBL1440395 0.83 GRIN2D (0.47) GAAHTTRHEBGRIN2DGRIN3B
SCHEMBL31748325 0.83 CSNK2A1 (0.44) GAAHTTRHEBGRIN2DGRIN3B
SCHEMBL1440519 0.83 GRIN2D (0.47) GAAHTTRHEBGRIN2DGRIN3B
SCHEMBL1440759 0.83 ALDH1A1 (0.47) GAAHTTRHEBGRIN2DGRIN3B
Hydrochloric Acid SCHEMBL1440703 0.81 GRIN2D (0.46) GAAHTTRHEBGRIN2DGRIN3B
Hydrochloric Acid SCHEMBL1440681 0.81 GRIN2D (0.46) GAAHTTRHEBGRIN2DGRIN3B
SCHEMBL2418522 0.78 EGLN1 (0.49) GAAHTTCACNA1GCACNA1HAR
SCHEMBL13394501 0.78 GAA (0.42) GAAHTTRHEBGRIN2DGRIN3B
SCHEMBL2418527 0.78 CACNA1H (0.46) GAAHTTRHEBCACNA1GCACNA1H

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 158 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-0845001-B1 5'-SUBSTITUTED-RIBOFURANOSYL BENZIMIDAZOLES AS ANTIVIRAL AGENTS UNIV MICHIGAN (US) 2002-11-13 EP claimed
US-20260070913-A1 7-AMINO-3,4-DIHYDROPYRIMIDOPYRIMIDIN-2-ONE DERIVATIVE HAVING INHIBITORY ACTIVITY FOR PROTEIN KINASES AND THERAPEUTIC PHARMACEUTICAL COMPOSITION COMPRISING SAME KOREA INST SCI & TECH (KR) 2026-03-12 US disclosed
EP-3854799-B1 CYCLIC DINUCLEOTIDE ANALOGUE, PHARMACEUTICAL COMPOSITION THEREOF, AND APPLICATION SHANGHAI DE NOVO PHARMATECH CO LTD (CN) 2024-07-17 EP disclosed
US-20240132479-A1 THERAPEUTIC COMPOUNDS AND USES THEREOF BOARD OF TRUSTEES OF MICHIGAN STATE UNIVERSITY 2024-04-25 US disclosed
US-20240051970-A1 COMPOUNDS AND COMPOSITIONS FOR TREATING CONDITIONS ASSOCIATED WITH STING ACTIVITY NOVARTIS PHARMA AG (CH) 2024-02-15 US disclosed
EP-4263531-A2 COMPOUNDS AND COMPOSITIONS FOR TREATING CONDITIONS ASSOCIATED WITH STING ACTIVITY IFM Due, Inc. (US) 2023-10-25 EP disclosed
US-20230103742-A1 7-AMINO-3,4-DIHYDROPYRIMIDOPYRIMIDIN-2-ONE DERIVATIVE HAVING INHIBITORY ACTIVITY FOR PROTEIN KINASES AND THERAPEUTIC PHARMACEUTICAL COMPOSITION COMPRISING SAME KOREA INSTITUTE OF SCIENCE AND TECHNOLOGY (KR) 2023-04-06 US disclosed
US-11618744-B2 Benzoimidazoles as prolyl hydroxylase inhibitors JANSSEN PHARMACEUTICA NV (BE) 2023-04-04 US disclosed
CN-114409657-B 4-aryl (methyl) imidazoline quinoxalinone compound and preparation method and application thereof 湖南科技大学 2023-02-24 CN disclosed
EP-4092029-A1 7-AMINO-3,4-DIHYDROPYRIMIDOPYRIMIDIN-2-ONE DERIVATIVE HAVING INHIBITORY ACTIVITY FOR PROTEIN KINASES AND THERAPEUTIC PHARMACEUTICAL COMPOSITION COMPRISING SAME Korea Institute of Science and Technology (KR) 2022-11-23 EP disclosed
US-5646125-A Polysubstituted benzimidazoles as antiviral agents THE REGENTS OF THE UNIVERSITY OF MICHIGAN (US) 1997-07-08 US disclosed
WO-1997007125-A1 5'-SUBSTITUTED-RIBOFURANOSYL BENZIMIDAZOLES AS ANTIVIRAL AGENTS THE REGENTS OF THE UNIVERSITY OF MICHIGAN (US) 1997-02-27 WO disclosed
US-5574058-A Polysubstituted benzimidazoles as antiviral agents THE REGENTS OF THE UNIVERSITY OF MICHIGAN (US) 1996-11-12 US disclosed
EP-0556334-A4 POLYSUBSTITUTED BENZIMIDAZOLES AS ANTIVIRAL AGENTS UNIV MICHIGAN (US) 1995-03-29 EP disclosed
US-5360795-A Treating cytomegalo virus and herpes simplex viruses THE REGENTS OF THE UNIVERSITY OF MICHIGAN (US) 1994-11-01 US disclosed
WO-1994008456-A1 POLYSUBSTITUTED BENZIMIDAZOLES AS ANTIVIRAL AGENTS THE REGENTS OF THE UNIVERSITY OF MICHIGAN (US) 1994-04-28 WO disclosed
US-5248672-A POLYSUBSTITUTED BENZIMIDAZOLE NUCLEOSIDES AS ANTIVIRAL AGENTS THE REGENTS OF THE UNIVERSITY OF MICHIGAN (US) 1993-09-28 US disclosed
EP-0556334-A1 POLYSUBSTITUTED BENZIMIDAZOLES AS ANTIVIRAL AGENTS THE REGENTS OF THE UNIVERSITY OF MICHIGAN (US) 1993-08-25 EP disclosed
WO-1992007867-A1 POLYSUBSTITUTED BENZIMIDAZOLES AS ANTIVIRAL AGENTS THE REGENTS OF THE UNIVERSITY OF MICHIGAN (US) 1992-05-14 WO disclosed
US-4000275-A BENZIMIDAZO(2,1-B) QUINAZOLIN-12(6H)ONES ELI LILLY AND COMPANY (US) 1976-12-28 US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (5 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-11618744-B2 Benzoimidazoles as prolyl hydroxylase inhibitors P4HA1, PAH, EGLN3 GAA 52/4885HTT 909/4885RHEB 1716/4885
US-20230103742-A1 7-AMINO-3,4-DIHYDROPYRIMIDOPYRIMIDIN-2-ONE DERIVATIVE HAVING INHIBITORY ACTIVITY FOR PROTEIN KINASES AND THERAPEUTIC PHARMACEUTICAL COMPOSITION COMPRISING SAME HASPIN, WEE2, CDK7 GAA 4108/4885HTT 3575/4885RHEB 1408/4885
US-20260070913-A1 7-AMINO-3,4-DIHYDROPYRIMIDOPYRIMIDIN-2-ONE DERIVATIVE HAVING INHIBITORY ACTIVITY FOR PROTEIN KINASES AND THERAPEUTIC PHARMACEUTICAL COMPOSITION COMPRISING SAME CSNK1A1, CKS1B, HGFAC GAA 4628/4885HTT 4337/4885RHEB 782/4885
US-20240132479-A1 THERAPEUTIC COMPOUNDS AND USES THEREOF CUTA, DCXR, PLOD3 GAA 3306/4885HTT 3946/4885RHEB 4002/4885
US-20240051970-A1 COMPOUNDS AND COMPOSITIONS FOR TREATING CONDITIONS ASSOCIATED WITH STING ACTIVITY STING1, CGAS, IRF3 GAA 184/4885HTT 2427/4885RHEB 1004/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.