Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 4/20 | 0.47 |
| ▸ | RAB9A | P51151 | 3/20 | 0.47 |
| ▸ | ABL1 | P00519 | 1/20 | 0.41 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.40 |
| ▸ | KDM6B | O15054 | 1/20 | 0.40 |
| ▸ | KDM5C | P41229 | 1/20 | 0.40 |
| ▸ | KDM4C | Q9H3R0 | 1/20 | 0.40 |
| ▸ | KDM2A | Q9Y2K7 | 1/20 | 0.40 |
| ▸ | KDM3A | Q9Y4C1 | 1/20 | 0.40 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.39 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.39 |
| ▸ | MEN1 | O00255 | 1/20 | 0.39 |
| ▸ | PKM | P14618 | 1/20 | 0.39 |
| ▸ | PLA2G2A | P14555 | 1/20 | 0.39 |
| ▸ | HPGD | P15428 | 2/20 | 0.38 |
| ▸ | LMNA | P02545 | 1/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.38 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.38 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5776738 | 0.96 | MAPT (0.50) | MAPTRAB9AABL1KDM4EKDM6B | |
| SCHEMBL2112969 | 0.91 | MAPT (0.47) | MAPTRAB9AABL1KDM4EKDM6B | |
| SCHEMBL5776743 | 0.89 | CYP2C9 (0.42) | MAPTRAB9ATDP1L3MBTL1KMT2A | |
| SCHEMBL6170674 | 0.82 | HIF1A (0.44) | RAB9AABL1KDM4EKDM6BKDM5C | |
| SCHEMBL7630706 | 0.82 | PKM (0.60) | MAPTRAB9AL3MBTL1PKMLMNA | |
| SCHEMBL4690379 | 0.81 | ABL1 (0.42) | MAPTRAB9AABL1KDM4ETDP1 | |
| SCHEMBL13250783 | 0.80 | ABL1 (0.40) | MAPTRAB9AABL1KDM4ETDP1 | |
| SCHEMBL5235828 | 0.79 | TSHR (0.46) | MAPTRAB9AABL1KDM4EL3MBTL1 | |
| SCHEMBL4690971 | 0.78 | KMT2A (0.36) | ABL1KDM4EKMT2AMEN1PKM | |
| SCHEMBL13250791 | 0.78 | LMNA (0.45) | MAPTRAB9AABL1KDM4ETDP1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1652839-A2 | Drug efflux pump inhibitor | DAIICHI PHARMACEUTICAL CO., LTD. (JP) | 2006-05-03 | — | — | EP | disclosed |
| EP-1227084-B1 | DRUG DISCHARGE PUMP INHIBITORS | TRINE PHARMACEUTICALS INC (US) | 2005-12-14 | — | — | EP | disclosed |
| EP-1227084-A1 | DRUG DISCHARGE PUMP INHIBITORS | Microcide Pharmaceuticals, Inc. (US) | 2002-07-31 | — | — | EP | disclosed |