Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP2C9 | P11712 | 1/20 | 0.42 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.42 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.42 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.42 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.40 |
| ▸ | POLB | P06746 | 2/20 | 0.40 |
| ▸ | MEN1 | O00255 | 2/20 | 0.40 |
| ▸ | CASP6 | P55212 | 1/20 | 0.40 |
| ▸ | PLA2G2A | P14555 | 1/20 | 0.40 |
| ▸ | MAPT | P10636 | 1/20 | 0.39 |
| ▸ | F2 | P00734 | 1/20 | 0.38 |
| ▸ | F10 | P00742 | 1/20 | 0.38 |
| ▸ | LMNA | P02545 | 1/20 | 0.38 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.38 |
| ▸ | PKM | P14618 | 1/20 | 0.37 |
| ▸ | BRD4 | O60885 | 1/20 | 0.36 |
| ▸ | BRD2 | P25440 | 1/20 | 0.36 |
| ▸ | CREBBP | Q92793 | 1/20 | 0.36 |
| ▸ | NPC1 | O15118 | 1/20 | 0.36 |
| ▸ | RAB9A | P51151 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5779621 | 0.89 | MAPT (0.47) | CYP2C9CYP2C19L3MBTL1TDP1KMT2A | |
| SCHEMBL5776738 | 0.85 | MAPT (0.50) | CYP2C9CYP2C19L3MBTL1TDP1KMT2A | |
| SCHEMBL2112969 | 0.80 | MAPT (0.47) | CYP2C9CYP2C19L3MBTL1TDP1KMT2A | |
| SCHEMBL7630706 | 0.80 | PKM (0.60) | L3MBTL1MAPTLMNAMAPK1PKM | |
| SCHEMBL4690971 | 0.76 | KMT2A (0.36) | KMT2AMEN1PLA2G2APKMALDH1A1 | |
| SCHEMBL2771704 | 0.74 | PLA2G2A (0.65) | CYP2C9CYP2C19L3MBTL1TDP1KMT2A | |
| SCHEMBL13250795 | 0.74 | ALDH1A1 (0.41) | L3MBTL1TDP1KMT2APOLBMEN1 | |
| SCHEMBL2818377 | 0.74 | L3MBTL1 (0.53) | L3MBTL1MAPTLMNAPKMRAB9A | |
| SCHEMBL3176831 | 0.74 | CYP2C9 (0.58) | CYP2C9CYP2C19TDP1KMT2AMEN1 | |
| SCHEMBL4195770 | 0.74 | MEN1 (0.70) | L3MBTL1KMT2AMEN1LMNAPKM |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1652839-A2 | Drug efflux pump inhibitor | DAIICHI PHARMACEUTICAL CO., LTD. (JP) | 2006-05-03 | — | — | EP | disclosed |
| EP-1227084-B1 | DRUG DISCHARGE PUMP INHIBITORS | TRINE PHARMACEUTICALS INC (US) | 2005-12-14 | — | — | EP | disclosed |
| EP-1227084-A1 | DRUG DISCHARGE PUMP INHIBITORS | Microcide Pharmaceuticals, Inc. (US) | 2002-07-31 | — | — | EP | disclosed |