Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR1A | P08908 | 2/20 | 0.39 |
| ▸ | DRD2 | P14416 | 1/20 | 0.39 |
| ▸ | HTR2A | P28223 | 1/20 | 0.39 |
| ▸ | HTR7 | P34969 | 1/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.37 |
| ▸ | ATM | Q13315 | 1/20 | 0.37 |
| ▸ | ADRA1D | P25100 | 10/20 | 0.36 |
| ▸ | ADRA1A | P35348 | 10/20 | 0.36 |
| ▸ | ADRA1B | P35368 | 10/20 | 0.36 |
| ▸ | ADRB2 | P07550 | 9/20 | 0.36 |
| ▸ | ADRB1 | P08588 | 9/20 | 0.36 |
| ▸ | ADRB3 | P13945 | 9/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.36 |
| ▸ | MEN1 | O00255 | 1/20 | 0.36 |
| ▸ | IGF1R | P08069 | 2/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5738728 | 0.91 | MEN1 (0.39) | HTR1AKMT2AMEN1 | |
| SCHEMBL5737988 | 0.89 | HTR1A (0.30) | HTR1ADRD2HTR2A | |
| SCHEMBL6400409 | 0.83 | — | — | |
| SCHEMBL5739938 | 0.80 | MAPT (0.42) | ALDH1A1 | |
| SCHEMBL5776547 | 0.79 | POLB (0.39) | HTR1A | |
| SCHEMBL6400812 | 0.78 | HTR2A (0.47) | HTR1ADRD2HTR2AHTR7 | |
| SCHEMBL6400851 | 0.75 | — | — | |
| SCHEMBL5738711 | 0.73 | MEN1 (0.39) | HTR1AKMT2AMEN1 | |
| SCHEMBL6399272 | 0.72 | DRD2 (0.44) | DRD2HTR2A | |
| SCHEMBL5738525 | 0.72 | HTR1A (0.44) | HTR1AHTR7 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1697334-A1 | HETEROCYCLIC SUBSTITUTED INDANE DERIVATIVES AND RELATED COMPOUNDS FOR THE TREATMENT OF SCHIZOPHRENIA | Warner-Lambert Company LLC (US) | 2006-09-06 | — | — | EP | disclosed |
| WO-2005056540-A1 | HETEROCYCLIC SUBSTITUTED INDANE DERIVATIVES AND RELATED COMPOUNDS FOR THE TREATMENT OF SCHIZOPHRENIA | WARNER-LAMBERT COMPANY LLC (US) | 2005-06-23 | — | — | WO | disclosed |