Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TRPA1 | O75762 | 1/20 | 0.43 |
| ▸ | IDO1 | P14902 | 3/20 | 0.36 |
| ▸ | TDO2 | P48775 | 1/20 | 0.36 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.36 |
| ▸ | CES2 | O00748 | 1/20 | 0.34 |
| ▸ | RPS6KA3 | P51812 | 1/20 | 0.34 |
| ▸ | JAK3 | P52333 | 1/20 | 0.34 |
| ▸ | GPBAR1 | Q8TDU6 | 4/20 | 0.34 |
| ▸ | RAPGEF3 | O95398 | 1/20 | 0.32 |
| ▸ | RAPGEF4 | Q8WZA2 | 1/20 | 0.32 |
| ▸ | KIF11 | P52732 | 1/20 | 0.31 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.31 |
| ▸ | PKM | P14618 | 1/20 | 0.31 |
| ▸ | TACR1 | P25103 | 2/20 | 0.31 |
| ▸ | GAA | P10253 | 1/20 | 0.31 |
| ▸ | CTSS | P25774 | 1/20 | 0.30 |
| ▸ | CTSK | P43235 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10959497 | 0.81 | TRPA1 (0.52) | TRPA1IDO1TDO2CES2GAA | |
| SCHEMBL11398665 | 0.79 | IDO1 (0.36) | IDO1TDO2CES2TACR1 | |
| SCHEMBL8073025 | 0.76 | TRPA1 (0.41) | TRPA1 | |
| SCHEMBL28061635 | 0.75 | TACR1 (0.37) | IDO1TDO2L3MBTL1CES2RPS6KA3 | |
| SCHEMBL28284728 | 0.75 | TACR1 (0.37) | IDO1TDO2L3MBTL1CES2RPS6KA3 | |
| SCHEMBL27268122 | 0.73 | CES2 (0.38) | IDO1TDO2L3MBTL1CES2RPS6KA3 | |
| SCHEMBL8700783 | 0.71 | TACR1 (0.40) | IDO1TDO2CES2RAPGEF4ALDH1A1 | |
| SCHEMBL264836 | 0.71 | TACR1 (0.40) | IDO1TDO2CES2RAPGEF4ALDH1A1 | |
| SCHEMBL1649435 | 0.71 | TACR1 (0.40) | IDO1TDO2CES2RAPGEF4ALDH1A1 | |
| SCHEMBL14321104 | 0.71 | IDO1 (0.39) | IDO1TDO2CES2ALDH1A1TACR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-1795177-A | 1, 2, 4-substituted 1, 2, 3, 4-tetrahydro-and 1, 2 dihydro-quinolines and 1, 2, 3, 4-tetrahydro-quinoxaline derivatives as CETP inhibitors for the treatment of atherosclerosis and obesity | PFIZER PROD INC (US) | 2006-06-28 | — | — | CN | disclosed |
| US-20060122224-A1 | Quinoline and quinoxaline compounds | BECHLE BRUCE M | 2006-06-08 | — | — | US | disclosed |
| EP-1622872-A1 | 1,2,4-SUBSTITUERTE 1,2,3,4-TETRAHYDRO-AND 1,2 DIHYDRO-QUINOLINE AND 1,2,3,4-TETRAHYDRO-QUINOXALINE DERIVATIVES AS CETP INHIBITORS FOR THE TREATMENT OF ATHEROSCLEROSIS AND OBESITY | Pfizer Products Inc. (US) | 2006-02-08 | — | — | EP | disclosed |
| WO-2006009819-A1 | INHIBITORS OF CHOLESTERYL ESTER TRANSFER PROTIEN | ARRAY BIOPHARMA INC. (US) | 2006-01-26 | — | — | WO | disclosed |
| US-20050282812-A1 | Inhibitors of cholesteryl ester transfer protein | ARRAY BIOPHARMA INC. | 2005-12-22 | — | — | US | disclosed |
| US-20040204450-A1 | Quinoline and quinoxaline compounds | PFIZER INC | 2004-10-14 | — | — | US | disclosed |
| WO-2004085401-A1 | 1,2,4-SUBSTITUTED 1,2,3,4-TETRAHYDRO-AND 1,2 DIHYDRO-QUINOLINE AND 1,2,3,4-TETRAHYDRO-QUINOXALINE DERIVATIVES AS CETP INHIBITORS FOR THE TREATMENT OF ATHEROSCLEROSIS AND OBESITY | PFIZER PRODUCTS INC. (US) | 2004-10-07 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20060122224-A1 | Quinoline and quinoxaline compounds | LDLR, APOB, PON1 | TRPA1 4260/4885IDO1 1293/4885TDO2 788/4885 |
| US-20040204450-A1 | Quinoline and quinoxaline compounds | LDLR, APOB, PON1 | TRPA1 4260/4885IDO1 1293/4885TDO2 788/4885 |
| US-20050282812-A1 | Inhibitors of cholesteryl ester transfer protein | CETP, LCAT, MTTP | TRPA1 4720/4885IDO1 4622/4885TDO2 4377/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.