Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KMT2A | Q03164 | 5/20 | 0.52 |
| ▸ | MEN1 | O00255 | 4/20 | 0.52 |
| ▸ | HTT | P42858 | 2/20 | 0.52 |
| ▸ | POLB | P06746 | 1/20 | 0.52 |
| ▸ | MAPT | P10636 | 4/20 | 0.50 |
| ▸ | ATM | Q13315 | 4/20 | 0.46 |
| ▸ | EPHX1 | P07099 | 3/20 | 0.46 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.43 |
| ▸ | LMNA | P02545 | 1/20 | 0.43 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.43 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.43 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.43 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.43 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.43 |
| ▸ | NPC1 | O15118 | 1/20 | 0.43 |
| ▸ | RAB9A | P51151 | 1/20 | 0.43 |
| ▸ | NAMPT | P43490 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5565031 | 0.83 | CNR1 (0.55) | KMT2AMEN1HTTPOLBMAPT | |
| SCHEMBL15601909 | 0.82 | MAPT (0.53) | KMT2AMEN1HTTPOLBMAPT | |
| SCHEMBL2597849 | 0.82 | HTT (0.64) | KMT2AMEN1HTTPOLBMAPT | |
| SCHEMBL6719494 | 0.80 | MAPT (0.50) | KMT2AMEN1HTTPOLBMAPT | |
| SCHEMBL6719504 | 0.79 | MAPT (0.49) | KMT2AMEN1HTTPOLBMAPT | |
| SCHEMBL5565500 | 0.78 | MAPT (0.48) | KMT2AMEN1HTTPOLBMAPT | |
| SCHEMBL6719499 | 0.78 | HTT (0.50) | KMT2AMEN1HTTPOLBMAPT | |
| SCHEMBL5565486 | 0.78 | MAPT (0.51) | KMT2AMEN1HTTPOLBMAPT | |
| SCHEMBL5565491 | 0.77 | MEN1 (0.46) | KMT2AMEN1HTTPOLBMAPT | |
| SCHEMBL5566673 | 0.76 | SMN1; SMN2 (0.49) | KMT2AMEN1HTTPOLBMAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1682531-A2 | SUBSTITUTED HETEROCYCLIC COMPOUNDS AND METHODS OF USE | AMGEN INC. (US) | 2006-07-26 | — | — | EP | disclosed |
| WO-2005042518-A2 | SUBSTITUTED HETEROCYCLIC COMPOUNDS AND METHODS OF USE | AMGEN INC. (US) | 2005-05-12 | — | — | WO | disclosed |