Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KLK7 | P49862 | 2/20 | 0.52 |
| ▸ | KLK5 | Q9Y337 | 2/20 | 0.52 |
| ▸ | MAPT | P10636 | 1/20 | 0.50 |
| ▸ | CTSK | P43235 | 2/20 | 0.49 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.49 |
| ▸ | CTSS | P25774 | 2/20 | 0.48 |
| ▸ | PTPN1 | P18031 | 1/20 | 0.47 |
| ▸ | CA1 | P00915 | 2/20 | 0.47 |
| ▸ | CA2 | P00918 | 1/20 | 0.47 |
| ▸ | CPB1 | P15086 | 1/20 | 0.46 |
| ▸ | CPB2 | Q96IY4 | 1/20 | 0.46 |
| ▸ | ITGB3 | P05106 | 1/20 | 0.46 |
| ▸ | ITGA2B | P08514 | 1/20 | 0.46 |
| ▸ | PTGER4 | P35408 | 1/20 | 0.46 |
| ▸ | CTSL | P07711 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5996732 | 0.89 | CTSK (0.61) | KLK7KLK5MAPTCTSKCTSS | |
| SCHEMBL5656256 | 0.85 | CTSK (0.54) | KLK7KLK5MAPTCTSKCTSS | |
| SCHEMBL7693003 | 0.85 | KLK7 (0.56) | KLK7KLK5MAPTCTSKSMN1; SMN2 | |
| SCHEMBL5653726 | 0.84 | KLK7 (0.51) | KLK7KLK5MAPTCTSKSMN1; SMN2 | |
| SCHEMBL4857149 | 0.83 | MAPT (0.58) | KLK7KLK5MAPTCTSKCTSS | |
| SCHEMBL25502674 | 0.82 | MAPT (0.60) | KLK7KLK5MAPTCTSKCTSS | |
| SCHEMBL5822432 | 0.82 | PTGER4 (0.51) | SMN1; SMN2CA1CA2CPB1CPB2 | |
| SCHEMBL30902907 | 0.82 | MAPT (0.65) | KLK7KLK5MAPTCTSKCTSS | |
| SCHEMBL16124431 | 0.82 | MAPT (0.60) | KLK7KLK5MAPTCTSKCTSS | |
| SCHEMBL23626336 | 0.81 | CPB1 (0.67) | KLK7KLK5MAPTCTSKCTSS |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1697337-A2 | ORNITHINE DERIVATIVES AS PROSTAGLANDIN-E2-AGONISTS OR ANTAGONISTS | Astellas Pharma Inc. (JP) | 2006-09-06 | — | — | EP | disclosed |
| WO-2005061475-A2 | ORNITHINE DERIVATIVES AS PROSTAGLANDIN E2 AGONISTS OR ANTAGONISTS | ASTELLAS PHARMA INC. (JP) | 2005-07-07 | — | — | WO | disclosed |