Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GNRHR | P30968 | 2/20 | 0.40 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.40 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.38 |
| ▸ | HSD11B1 | P28845 | 1/20 | 0.37 |
| ▸ | CRHR1 | P34998 | 2/20 | 0.37 |
| ▸ | CHRM1 | P11229 | 4/20 | 0.36 |
| ▸ | CHRM2 | P08172 | 1/20 | 0.35 |
| ▸ | CHRM3 | P20309 | 1/20 | 0.35 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.34 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.34 |
| ▸ | HTR2B | P41595 | 1/20 | 0.34 |
| ▸ | MAPK14 | Q16539 | 1/20 | 0.34 |
| ▸ | PDK1 | Q15118 | 3/20 | 0.34 |
| ▸ | PDK2 | Q15119 | 3/20 | 0.34 |
| ▸ | PDK3 | Q15120 | 3/20 | 0.34 |
| ▸ | PDK4 | Q16654 | 3/20 | 0.34 |
| ▸ | P2RX7 | Q99572 | 1/20 | 0.34 |
| ▸ | PSEN1 | P49768 | 2/20 | 0.33 |
| ▸ | PSEN2 | P49810 | 2/20 | 0.33 |
| ▸ | APH1B | Q8WW43 | 2/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5599374 | 1.00 | GNRHR (0.40) | GNRHRKCNH2RXFP1HSD11B1CRHR1 | |
| SCHEMBL5782306 | 0.91 | HTR2A (0.40) | GNRHRKCNH2HSD11B1CYP2C9CYP2C19 | |
| SCHEMBL5782925 | 0.87 | LMNA (0.39) | HSD11B1CYP2C9CYP2C19MAPK14 | |
| SCHEMBL5600002 | 0.87 | P2RX7 (0.37) | GNRHRKCNH2CRHR1CHRM1CYP2C19 | |
| SCHEMBL5599358 | 0.87 | PARP1 (0.36) | GNRHRKCNH2CRHR1CHRM1PDK1 | |
| SCHEMBL5783985 | 0.87 | DPP4 (0.34) | GNRHRKCNH2CRHR1PDK1PDK2 | |
| SCHEMBL5599096 | 0.86 | GNRHR (0.41) | GNRHRKCNH2RXFP1HSD11B1PDK1 | |
| SCHEMBL5786887 | 0.86 | GNRHR (0.41) | GNRHRKCNH2RXFP1HSD11B1CRHR1 | |
| SCHEMBL5599203 | 0.85 | GNRHR (0.39) | GNRHRKCNH2RXFP1HSD11B1CYP2C9 | |
| SCHEMBL5600630 | 0.85 | GNRHR (0.36) | GNRHRKCNH2CRHR1CHRM1CHRM2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2005063745-A9 | NOVEL SPIROINDOLINE OR SPIROISOQUINOLINE COMPOUNDS, METHODS OF USE AND COMPOSITIONS THEREOF | ARENA PHARM INC (US) | 2007-02-01 | — | — | WO | claimed |