Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GRM5 | P41594 | 1/20 | 0.45 |
| ▸ | FABP3 | P05413 | 1/20 | 0.42 |
| ▸ | FABP4 | P15090 | 1/20 | 0.42 |
| ▸ | CNR2 | P34972 | 1/20 | 0.41 |
| ▸ | HPD | P32754 | 3/20 | 0.41 |
| ▸ | DHODH | Q02127 | 1/20 | 0.40 |
| ▸ | TP53 | P04637 | 1/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.40 |
| ▸ | MEN1 | O00255 | 1/20 | 0.40 |
| ▸ | HCRTR1 | O43613 | 1/20 | 0.40 |
| ▸ | PIN1 | Q13526 | 1/20 | 0.40 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.40 |
| ▸ | MAP4K4 | O95819 | 1/20 | 0.40 |
| ▸ | LTB4R | Q15722 | 1/20 | 0.39 |
| ▸ | LMNA | P02545 | 1/20 | 0.39 |
| ▸ | HTT | P42858 | 1/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.39 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6310079 | 0.88 | CNR1 (0.42) | GRM5FABP3FABP4CNR2KDM4E | |
| Hydrochloric Acid SCHEMBL5656211 | 0.87 | CNR1 (0.41) | GRM5FABP3FABP4CNR2KDM4E | |
| SCHEMBL5656596 | 0.85 | LTB4R (0.46) | GRM5TP53KDM4EMAP4K4LTB4R | |
| SCHEMBL5782390 | 0.82 | CNR2 (0.52) | GRM5FABP3FABP4CNR2DHODH | |
| SCHEMBL5782688 | 0.81 | CSNK2A2 (0.46) | GRM5FABP3FABP4HPDDHODH | |
| SCHEMBL14039064 | 0.78 | CSNK2A2 (0.47) | TP53KMT2AKDM4ELMNAALDH1A1 | |
| SCHEMBL5655139 | 0.78 | LTB4R (0.44) | CNR2HPDHCRTR1MAP4K4LTB4R | |
| SCHEMBL24975611 | 0.76 | IP6K1 (0.55) | TP53KMT2AMEN1KDM4ELMNA | |
| SCHEMBL31429025 | 0.76 | IP6K1 (0.55) | TP53KMT2AMEN1KDM4ELMNA | |
| SCHEMBL28883104 | 0.76 | MAPK1 (0.61) | FABP3FABP4DHODHKMT2AMEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7053105-B2 | Farnesyl transferase inhibiting quinoline and quinazoline derivatives as farnesyl transferase inhibitors | JANSSEN PHARMACEUTICA, N.V. (BE) | 2006-05-30 | — | — | US | disclosed |
| EP-1322635-B1 | FARNESYL TRANSFERASE INHIBITING QUINOLINE AND QUINAZOLINE DERIVATIVES AS FARNESYL TRANSFERASE INHIBITORS | JANSSEN PHARMACEUTICA NV (BE) | 2006-03-22 | — | — | EP | disclosed |
| US-20030203904-A1 | Farnesyl transferase inhibiting quinoline and quinazoline derivatives as farnesyl transferase inhibitors | JANSSEN PHARMACEUTICA N.V. (BE) | 2003-10-30 | — | — | US | disclosed |
| EP-1322635-A1 | FARNESYL TRANSFERASE INHIBITING QUINOLINE AND QUINAZOLINE DERIVATIVES AS FARNESYL TRANSFERASE INHIBITORS | JANSSEN PHARMACEUTICA N.V. (BE) | 2003-07-02 | — | — | EP | disclosed |
| WO-2002024682-A1 | FARNESYL TRANSFERASE INHIBITING QUINOLINE AND QUINAZOLINE DERIVATIVES AS FARNESYL TRANSFERASE INHIBITORS | JANSSEN PHARMACEUTICA N.V. (BE) | 2002-03-28 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20030203904-A1 | Farnesyl transferase inhibiting quinoline and quinazoline derivatives as farnesyl transferase inhibitors | FNTA, FNTB, RABGGTB | GRM5 4137/4885FABP3 517/4885FABP4 2317/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.