Sugi Predict

Sugi Predict / Compounds / SCHEMBL5783207

SCHEMBL5783207

SCHEMBL5783207

CC(=O)c1ccc(S(=O)(=O)N2CCC(N3COCc4cccc(C)c43)CC2)cc1.Cc1cccc2c1N(C1CCN(S(=O)(=O)c3cccs3)CC1)C(=O)OC2

nearest known ligand 0.51

Predicted protein targets (top 7)

geneUniProtsupporting neighboursconfidence
▸ HTR6 P50406 6/20 0.51
▸ NPC1 O15118 2/20 0.43
▸ RAB9A P51151 2/20 0.43
▸ MAPT P10636 1/20 0.43
▸ GAA P10253 1/20 0.40
▸ LMNA P02545 1/20 0.36
▸ POLB P06746 1/20 0.36

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL3152681 0.86 HTR6 (0.65) HTR6NPC1RAB9AMAPTLMNA
SCHEMBL5438243 0.85 LMNA (0.47) HTR6NPC1RAB9AMAPTGAA
SCHEMBL3149395 0.84 HTR6 (0.68) HTR6RAB9APOLB
SCHEMBL5785377 0.77 HTR6 (0.64) HTR6
SCHEMBL3148482 0.76 HTR6 (0.70) HTR6GAALMNA
SCHEMBL5815985 0.76 HTR6 (0.52) HTR6POLB
SCHEMBL5783801 0.76 HTR6 (0.54) HTR6
SCHEMBL14093833 0.75 HTR6 (0.69) HTR6LMNA
SCHEMBL3143762 0.75 HTR6 (0.69) HTR6LMNA
SCHEMBL3148210 0.75 HTR6 (0.74) HTR6

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-1648886-A1 BENZOXAZINONE-DERIVED SULFONAMIDE COMPOUNDS, THEIR PREPARATION AND USE AS MEDICAMENTS LABORATORIOS DEL DR. ESTEVE, S.A. (ES) 2006-04-26 — — EP claimed
WO-2005014589-A1 BENZOXAZINONE-DERIVED SULFONAMIDE COMPOUNDS, THEIR PREPARATION AND USE AS MEDICAMENTS LABORATORIOS DEL DR. ESTEVE S.A. (DE) 2005-02-17 — — WO claimed