SCHEMBL5784679

SCHEMBL5784679

COc1cccc(NC(=O)CCC(=O)Nc2ccc(C(C)=O)c(OC)c2)c1

nearest known ligand 0.62

Predicted protein targets (top 17)

geneUniProtsupporting neighboursconfidence
MTNR1B P49286 2/20 0.58
RAB9A P51151 2/20 0.58
POLB P06746 2/20 0.58
MTNR1A P48039 1/20 0.57
GAA P10253 1/20 0.57
ALOX15 P16050 1/20 0.57
L3MBTL1 Q9Y468 1/20 0.57
SMN1; SMN2 Q16637 3/20 0.57
TP53 P04637 2/20 0.56
NPC1 O15118 2/20 0.56
CASP3 P42574 1/20 0.56
RXFP1 Q9HBX9 1/20 0.55
MEN1 O00255 1/20 0.54
KMT2A Q03164 1/20 0.54
HPGD P15428 2/20 0.54
USP2 O75604 1/20 0.54
ALDH1A1 P00352 1/20 0.54

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL5784671 0.88 MTNR1A (0.64) MTNR1BRAB9APOLBMTNR1ASMN1; SMN2
SCHEMBL3145750 0.80 RAB9A (0.72) MTNR1BRAB9AMTNR1AGAAALOX15
SCHEMBL3145742 0.80 RAB9A (0.72) MTNR1BRAB9AMTNR1AGAAALOX15
SCHEMBL8278751 0.78 MTNR1B (0.89) MTNR1BRAB9AMTNR1AGAAALOX15
SCHEMBL23080160 0.78 MTNR1B (0.70) MTNR1BRAB9APOLBMTNR1AGAA
SCHEMBL5142657 0.78 NPC1 (0.75) MTNR1BRAB9AMTNR1AGAAALOX15
SCHEMBL27303084 0.78 MTNR1B (0.65) MTNR1BRAB9AMTNR1AGAAALOX15
SCHEMBL27300887 0.78 MTNR1B (0.65) MTNR1BRAB9AMTNR1AGAAALOX15
SCHEMBL4611370 0.77 MTNR1B (0.72) MTNR1BRAB9APOLBMTNR1AGAA
SCHEMBL8288208 0.77 MTNR1B (0.68) MTNR1BRAB9APOLBMTNR1AGAA

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-1725540-A1 DIAMINOPYRIMIDINES AS P2X3 AND P2X2/3 ANTAGONISTS F.HOFFMANN-LA ROCHE AG (CH) 2006-11-29 EP disclosed
WO-2005095359-A1 DIAMINOPYRIMIDINES AS P2X3 AND P2X2/3 ANTAGONISTS F. HOFFMANN-LA ROCHE AG (CH) 2005-10-13 WO disclosed