Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 6/20 | 0.62 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.62 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.62 |
| ▸ | TSHR | P16473 | 1/20 | 0.62 |
| ▸ | LMNA | P02545 | 3/20 | 0.61 |
| ▸ | POLB | P06746 | 2/20 | 0.60 |
| ▸ | KMT2A | Q03164 | 5/20 | 0.60 |
| ▸ | MAPT | P10636 | 5/20 | 0.60 |
| ▸ | MEN1 | O00255 | 4/20 | 0.60 |
| ▸ | RAB9A | P51151 | 3/20 | 0.60 |
| ▸ | HTT | P42858 | 2/20 | 0.60 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.60 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.60 |
| ▸ | F2 | P00734 | 1/20 | 0.53 |
| ▸ | NPC1 | O15118 | 2/20 | 0.52 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2749120 | 0.95 | ALDH1A1 (0.69) | ALDH1A1TDP1CYP3A4TSHRLMNA | |
| SCHEMBL8306021 | 0.81 | RAB9A (0.63) | ALDH1A1LMNAPOLBKMT2AMAPT | |
| SCHEMBL2747530 | 0.80 | ALDH1A1 (0.60) | ALDH1A1TDP1CYP3A4TSHRLMNA | |
| SCHEMBL11223073 | 0.80 | MEN1 (0.75) | ALDH1A1TDP1CYP3A4TSHRLMNA | |
| SCHEMBL15043007 | 0.78 | MAPT (0.66) | ALDH1A1TDP1CYP3A4TSHRLMNA | |
| SCHEMBL19034437 | 0.77 | ALDH1A1 (1.00) | ALDH1A1TDP1CYP3A4TSHRLMNA | |
| SCHEMBL11835490 | 0.77 | NPC1 (0.57) | ALDH1A1LMNAPOLBKMT2AMAPT | |
| SCHEMBL13202288 | 0.76 | F2 (0.64) | ALDH1A1LMNAPOLBKMT2AMEN1 | |
| SCHEMBL5740018 | 0.76 | TTR (0.61) | ALDH1A1TDP1CYP3A4TSHRPOLB | |
| SCHEMBL16996704 | 0.75 | RAB9A (0.66) | ALDH1A1TSHRKMT2AMEN1RAB9A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1713484-A2 | COMPOUNDS AND METHODS OF USE | AMGEN INC. (US) | 2006-10-25 | — | — | EP | disclosed |
| WO-2005070891-A2 | COMPOUNDS AND METHODS OF USE | AMGEN INC (US) | 2005-08-04 | — | — | WO | disclosed |