Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CCR3 | P51677 | 2/20 | 0.48 |
| ▸ | FPR2 | P25090 | 1/20 | 0.46 |
| ▸ | PROKR1 | Q8TCW9 | 1/20 | 0.46 |
| ▸ | SIGMAR1 | Q99720 | 9/20 | 0.43 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.43 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.43 |
| ▸ | TMEM97 | Q5BJF2 | 1/20 | 0.43 |
| ▸ | PRMT3 | O60678 | 1/20 | 0.43 |
| ▸ | CARM1 | Q86X55 | 1/20 | 0.43 |
| ▸ | PRMT6 | Q96LA8 | 1/20 | 0.43 |
| ▸ | PRMT1 | Q99873 | 1/20 | 0.43 |
| ▸ | PRMT8 | Q9NR22 | 1/20 | 0.43 |
| ▸ | HTR7 | P34969 | 2/20 | 0.42 |
| ▸ | CCR5 | P51681 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7872233 | 1.00 | CCR3 (0.48) | CCR3FPR2PROKR1SIGMAR1CYP1A2 | |
| SCHEMBL24069004 | 0.83 | PRMT3 (0.61) | CCR3FPR2PROKR1SIGMAR1CYP1A2 | |
| SCHEMBL5781019 | 0.82 | SIGMAR1 (0.56) | CCR3SIGMAR1CYP1A2CYP2D6TMEM97 | |
| SCHEMBL4960083 | 0.78 | CCR3 (0.53) | CCR3FPR2PROKR1 | |
| SCHEMBL5743381 | 0.78 | CCR3 (0.53) | CCR3FPR2PROKR1 | |
| SCHEMBL4959466 | 0.78 | CCR3 (0.57) | CCR3FPR2PROKR1SIGMAR1 | |
| SCHEMBL4959461 | 0.78 | CCR3 (0.57) | CCR3FPR2PROKR1SIGMAR1 | |
| SCHEMBL5744458 | 0.78 | CCR3 (0.57) | CCR3FPR2PROKR1SIGMAR1 | |
| SCHEMBL5784473 | 0.77 | PRMT6 (0.43) | CCR3CARM1PRMT6CCR5 | |
| SCHEMBL7514185 | 0.77 | HRH1 (0.52) | CCR3FPR2PROKR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1680408-A2 | CCR3 RECEPTOR ANTAGONISTS | F. HOFFMANN-LA ROCHE AG (CH) | 2006-07-19 | — | — | EP | disclosed |
| WO-2005040129-A2 | CCR3 RECEPTOR ANTAGONISTS | F. HOFFMANN-LA ROCHE AG (CH) | 2005-05-06 | — | — | WO | disclosed |