Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR2C | P28335 | 5/20 | 0.61 |
| ▸ | HTR2A | P28223 | 3/20 | 0.61 |
| ▸ | HTR2B | P41595 | 3/20 | 0.61 |
| ▸ | SLC6A4 | P31645 | 2/20 | 0.60 |
| ▸ | ADRB2 | P07550 | 1/20 | 0.59 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.52 |
| ▸ | ATM | Q13315 | 1/20 | 0.52 |
| ▸ | HTR1D | P28221 | 1/20 | 0.50 |
| ▸ | HTR1B | P28222 | 1/20 | 0.50 |
| ▸ | BRD4 | O60885 | 1/20 | 0.49 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.49 |
| ▸ | POLB | P06746 | 1/20 | 0.49 |
| ▸ | CREBBP | Q92793 | 1/20 | 0.49 |
| ▸ | ADRA1D | P25100 | 3/20 | 0.47 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5785331 | 1.00 | HTR2C (0.61) | HTR2CHTR2AHTR2BSLC6A4ADRB2 | |
| SCHEMBL5788471 | 1.00 | HTR2C (0.61) | HTR2CHTR2AHTR2BSLC6A4ADRB2 | |
| SCHEMBL5788466 | 1.00 | HTR2C (0.61) | HTR2CHTR2AHTR2BSLC6A4ADRB2 | |
| SCHEMBL5785328 | 1.00 | HTR2C (0.61) | HTR2CHTR2AHTR2BSLC6A4ADRB2 | |
| SCHEMBL23649321 | 0.91 | HTR2C (0.58) | HTR2CHTR2AHTR2BSLC6A4ADRB2 | |
| SCHEMBL29824695 | 0.91 | HTR2C (0.58) | HTR2CHTR2AHTR2BSLC6A4ADRB2 | |
| SCHEMBL734917 | 0.84 | HTR2C (0.79) | HTR2CHTR2AHTR2BSLC6A4ADRB2 | |
| SCHEMBL28320141 | 0.79 | SLC6A4 (0.46) | HTR2CHTR2AHTR2BSLC6A4ADRB2 | |
| SCHEMBL3888648 | 0.79 | SLC6A4 (0.66) | HTR2CHTR2AHTR2BSLC6A4HTR1D | |
| SCHEMBL3886779 | 0.79 | SLC6A4 (0.66) | HTR2CHTR2AHTR2BSLC6A4HTR1D |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1546151-B1 | ANTIDEPRESSANT CYCLOALKYLAMINE DERIVATIVES OF HETEROCYCLE-FUSED BENZODIOXANS | WYETH CORP (US) | 2006-04-12 | — | — | EP | disclosed |
| EP-1546151-A1 | ANTIDEPRESSANT CYCLOALKYLAMINE DERIVATIVES OF HETEROCYCLE-FUSED BENZODIOXANS | Wyeth (US) | 2005-06-29 | — | — | EP | disclosed |
| US-6911445-B2 | For reatment of depression, childhood depression, dysthymia, anxiety, panic disorder, post-traumatic stress disorder, premenstrual dysphoric disorder, attention deficit disorder, obsessive-compulsive disorder, cocaine and alcohol addiction | WYETH (US) | 2005-06-28 | — | — | US | disclosed |
| US-20040171667-A1 | Antidepressant cycloalkylamine derivatives of heterocycle-fused benzodioxans | WYETH | 2004-09-02 | — | — | US | disclosed |
| WO-2004024732-A1 | ANTIDEPRESSANT CYCLOALKYLAMINE DERIVATIVES OF HETEROCYCLE-FUSED BENZODIOXANS | WYETH (US) | 2004-03-25 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20040171667-A1 | Antidepressant cycloalkylamine derivatives of heterocycle-fused benzodioxans | HTR5A, CRH, TPH1 | HTR2C 12/4885HTR2A 45/4885HTR2B 21/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.