Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KCNH2 | Q12809 | 1/20 | 0.53 |
| ▸ | EPHX2 | P34913 | 4/20 | 0.52 |
| ▸ | FAAH | O00519 | 2/20 | 0.52 |
| ▸ | AADAC | P22760 | 1/20 | 0.52 |
| ▸ | CHRM4 | P08173 | 3/20 | 0.49 |
| ▸ | FFAR4 | Q5NUL3 | 2/20 | 0.45 |
| ▸ | PTGS1 | P23219 | 1/20 | 0.44 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.44 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.44 |
| ▸ | MMP2 | P08253 | 1/20 | 0.44 |
| ▸ | MMP13 | P45452 | 1/20 | 0.44 |
| ▸ | FPR2 | P25090 | 2/20 | 0.43 |
| ▸ | PROKR1 | Q8TCW9 | 2/20 | 0.43 |
| ▸ | FFAR1 | O14842 | 3/20 | 0.43 |
| ▸ | ACACB | O00763 | 1/20 | 0.43 |
| ▸ | PDE3B | Q13370 | 1/20 | 0.43 |
| ▸ | PDE3A | Q14432 | 1/20 | 0.43 |
| ▸ | KCNA5 | P22460 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13281330 | 1.00 | KCNH2 (0.53) | KCNH2EPHX2FAAHAADACCHRM4 | |
| SCHEMBL3036120 | 0.99 | KCNH2 (0.52) | KCNH2EPHX2FAAHAADACCHRM4 | |
| SCHEMBL15441879 | 0.96 | KCNH2 (0.50) | KCNH2EPHX2FAAHAADACCHRM4 | |
| SCHEMBL13278969 | 0.91 | KCNH2 (0.53) | KCNH2EPHX2FAAHAADACCHRM4 | |
| SCHEMBL14405200 | 0.89 | KCNH2 (0.46) | KCNH2EPHX2FAAHAADACCHRM4 | |
| SCHEMBL2095407 | 0.89 | KCNH2 (0.46) | KCNH2EPHX2FAAHAADACCHRM4 | |
| Oxazole SCHEMBL5711296 | 0.87 | KCNH2 (0.48) | KCNH2EPHX2FAAHAADACCHRM4 | |
| SCHEMBL2056202 | 0.86 | KCNH2 (0.58) | KCNH2EPHX2FAAHCHRM4FFAR4 | |
| SCHEMBL13279685 | 0.86 | DEGS1 (0.48) | EPHX2MMP2MMP13FPR2PROKR1 | |
| SCHEMBL5541736 | 0.86 | DEGS1 (0.48) | EPHX2MMP2MMP13FPR2PROKR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 77 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-107406386-B | Process for producing 1- (4-hydroxyphenyl) -4- (4-trifluoromethoxyphenoxy) piperidine or salt thereof | 大塚制药株式会社 | 2021-06-01 | — | — | CN | claimed |
| EP-3275862-B1 | METHOD FOR PRODUCING 1-(4-HYDROXYPHENYL)-4-(4-TRIFLUOROMETHOXYPHENOXY)PIPERIDINE OR SALT THEREOF | OTSUKA PHARMA CO LTD (JP) | 2020-08-12 | — | — | EP | claimed |
| US-10252995-B2 | Method for producing 1-(4-hydroxyphenyl)-4-(4-trifluoromethoxyphenoxy)piperidine or salt thereof | OTSUKA PHARMACEUTICAL CO., LTD. (JP) | 2019-04-09 | — | — | US | claimed |
| US-20180065931-A1 | METHOD FOR PRODUCING 1-(4-HYDROXYPHENYL)-4-(4-TRIFLUOROMETHOXYPHENOXY)PIPERIDINE OR SALT THEREOF | OTSUKA PHARMACEUTICAL CO., LTD. (JP) | 2018-03-08 | — | — | US | claimed |
| EP-3275862-A1 | METHOD FOR PRODUCING 1-(4-HYDROXYPHENYL)-4-(4-TRIFLUOROMETHOXYPHENOXY)PIPERIDINE OR SALT THEREOF | Otsuka Pharmaceutical Co., Ltd. (JP) | 2018-01-31 | — | — | EP | claimed |
| EP-1727782-B1 | METHOD OF PRODUCING AMINOPHENOL COMPOUNDS | OTSUKA PHARMA CO LTD (JP) | 2012-08-22 | — | — | EP | claimed |
| US-7750156-B2 | Method of producing aminophenol compounds | OTSUKA PHARMACEUTICAL CO., LTD. (JP) | 2010-07-06 | — | — | US | claimed |
| US-20070219374-A1 | Method of Producing Aminophenol Compounds | OTSUKA PHARMACEUTICAL CO., LTD. (JP) | 2007-09-20 | — | — | US | claimed |
| EP-1727782-A1 | METHOD OF PRODUCING AMINOPHENOL COMPOUNDS | OTSUKA PHARMACEUTICAL CO., LTD. (JP) | 2006-12-06 | — | — | EP | claimed |
| WO-2005092832-A1 | METHOD OF PRODUCING AMINOPHENOL COMPOUNDS | OTSUKA PHARMACEUTICAL CO., LTD. (JP) | 2005-10-06 | — | — | WO | claimed |
| CN-113874341-B | Process for preparing derivatives of 1, 1-dialkylethane-1, 2-diols useful as intermediates | 科学与工业研究委员会 | 2024-05-31 | — | — | CN | disclosed |
| CN-110857294-B | Crystal form of diramanib intermediate and preparation method thereof | 华北制药集团新药研究开发有限责任公司 | 2022-11-18 | — | — | CN | disclosed |
| CN-113874341-A | Process for preparing derivatives of 1, 1-dialkylethane-1, 2-diols as useful intermediates | 科学与工业研究委员会 | 2021-12-31 | — | — | CN | disclosed |
| CN-107406386-B | Process for producing 1- (4-hydroxyphenyl) -4- (4-trifluoromethoxyphenoxy) piperidine or salt thereof | 大塚制药株式会社 | 2021-06-01 | — | — | CN | disclosed |
| CN-107406386-B | Process for producing 1- (4-hydroxyphenyl) -4- (4-trifluoromethoxyphenoxy) piperidine or salt thereof | 大塚制药株式会社 | 2021-06-01 | — | — | CN | disclosed |
| US-20060094767-A1 | 2,3-Dihydro-6-nitroimidazo[2,1-b]oxazoles | OTSUKA PHARMACEUTICAL CO., LTD. (JP) | 2006-05-04 | — | — | US | disclosed |
| US-20060079697-A1 | 1-substituted-4-nitroimidazole compound and process for producing the same | OTSUKA PHARMACEUTICAL CO., LTD. (JP) | 2006-04-13 | — | — | US | disclosed |
| WO-2005092832-A1 | METHOD OF PRODUCING AMINOPHENOL COMPOUNDS | OTSUKA PHARMACEUTICAL CO., LTD. (JP) | 2005-10-06 | — | — | WO | disclosed |
| EP-1555267-A1 | 2,3-DIHYDRO-6-NITROIMIDAZO 2,1-b OXAZOLES | OTSUKA PHARMACEUTICAL CO., LTD. (JP) | 2005-07-20 | — | — | EP | disclosed |
| EP-1553088-A1 | 1-SUBSTITUTED 4-NITROIMIDAZOLE COMPOUND AND PROCESS FOR PRODUCING THE SAME | Otsuka Pharmaceutical Company, Limited (JP) | 2005-07-13 | — | — | EP | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (5 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20180065931-A1 | METHOD FOR PRODUCING 1-(4-HYDROXYPHENYL)-4-(4-TRIFLUOROMETHOXYPHENOXY)PIPERIDINE OR SALT THEREOF | DHPS, PAH, HPD | KCNH2 174/4885EPHX2 1064/4885FAAH 2709/4885 |
| US-20060094767-A1 | 2,3-Dihydro-6-nitroimidazo[2,1-b]oxazoles | NR2C2, NR4A3, NR4A2 | KCNH2 3503/4885EPHX2 3662/4885FAAH 4363/4885 |
| US-20060079697-A1 | 1-substituted-4-nitroimidazole compound and process for producing the same | CBR1, CBR3, DCXR | KCNH2 1539/4885EPHX2 3822/4885FAAH 3979/4885 |
| US-20070219374-A1 | Method of Producing Aminophenol Compounds | PAH, CYP1A1, CYP1B1 | KCNH2 3236/4885EPHX2 995/4885FAAH 2103/4885 |
| US-10252995-B2 | Method for producing 1-(4-hydroxyphenyl)-4-(4-trifluoromethoxyphenoxy)piperidine or salt thereof | DHPS, PAH, HPD | KCNH2 174/4885EPHX2 1064/4885FAAH 2709/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.