Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR6 | P50406 | 14/20 | 0.64 |
| ▸ | PRKCB | P05771 | 2/20 | 0.50 |
| ▸ | PRKCA | P17252 | 2/20 | 0.50 |
| ▸ | CNR2 | P34972 | 1/20 | 0.50 |
| ▸ | PRKCE | Q02156 | 1/20 | 0.50 |
| ▸ | TP53 | P04637 | 1/20 | 0.48 |
| ▸ | GAA | P10253 | 1/20 | 0.48 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.47 |
| ▸ | HTR2A | P28223 | 1/20 | 0.47 |
| ▸ | HTR7 | P34969 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5782859 | 0.92 | HTR6 (0.67) | HTR6CNR2 | |
| SCHEMBL5782703 | 0.82 | HTR6 (0.58) | HTR6 | |
| SCHEMBL5785029 | 0.82 | HTR6 (0.84) | HTR6TP53GAA | |
| Hydrochloric Acid SCHEMBL5786408 | 0.81 | HTR6 (0.82) | HTR6TP53GAA | |
| SCHEMBL5784717 | 0.79 | HTR6 (0.63) | HTR6TP53GAA | |
| SCHEMBL5787166 | 0.79 | HTR6 (1.00) | HTR6HTR2AHTR7 | |
| SCHEMBL5783823 | 0.79 | HTR6 (0.85) | HTR6TP53GAA | |
| SCHEMBL9540544 | 0.77 | PLK1 (0.66) | PRKCBPRKCACNR2PRKCEHTR7 | |
| SCHEMBL5787373 | 0.77 | HTR6 (0.65) | HTR6 | |
| SCHEMBL13806551 | 0.76 | HRH3 (0.51) | PRKCBPRKCACNR2PRKCEHTR7 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1509501-B1 | 1-(AMINOALKYL)-3-SULFONYLINDOLE AND -INDAZOLE DERIVATIVES AS 5-HYDROXYTRYPTAMINE-6 LIGANDS | WYETH CORP (US) | 2006-12-20 | — | — | EP | claimed |
| US-6727246-B2 | ENHANCEMENT OF COGNITION AND MEMORY IN HUMAN DISEASES SUCH AS ALZHEIMER'S | WYETH | 2004-04-27 | — | — | US | claimed |
| US-20030232828-A1 | 1-(AMINOALKYL)-3-SULFONYLINDOLE AND-INDAZOLE DERIVATIVES AS 5-HYDROXYTRYPTAMINE-6 LIGANDS | WYETH | 2003-12-18 | — | — | US | claimed |
| EP-1509501-B1 | 1-(AMINOALKYL)-3-SULFONYLINDOLE AND -INDAZOLE DERIVATIVES AS 5-HYDROXYTRYPTAMINE-6 LIGANDS | WYETH CORP (US) | 2006-12-20 | — | — | EP | disclosed |
| US-6727246-B2 | ENHANCEMENT OF COGNITION AND MEMORY IN HUMAN DISEASES SUCH AS ALZHEIMER'S | WYETH | 2004-04-27 | — | — | US | disclosed |
| US-20030232828-A1 | 1-(AMINOALKYL)-3-SULFONYLINDOLE AND-INDAZOLE DERIVATIVES AS 5-HYDROXYTRYPTAMINE-6 LIGANDS | WYETH | 2003-12-18 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20030232828-A1 | 1-(AMINOALKYL)-3-SULFONYLINDOLE AND-INDAZOLE DERIVATIVES AS 5-HYDROXYTRYPTAMINE-6 LIGANDS | HTR6, HTR3A, HTR5A | HTR6 1/4885PRKCB 4558/4885PRKCA 4661/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.