Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NPC1 | O15118 | 1/20 | 0.61 |
| ▸ | RAB9A | P51151 | 1/20 | 0.61 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.61 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.61 |
| ▸ | IKBKB | O14920 | 1/20 | 0.42 |
| ▸ | MAP3K8 | P41279 | 4/20 | 0.41 |
| ▸ | TYK2 | P29597 | 1/20 | 0.41 |
| ▸ | EGFR | P00533 | 5/20 | 0.41 |
| ▸ | TUBB4A | P04350 | 1/20 | 0.41 |
| ▸ | TUBB | P07437 | 1/20 | 0.41 |
| ▸ | TUBA3C | P0DPH7 | 1/20 | 0.41 |
| ▸ | TUBA1B | P68363 | 1/20 | 0.41 |
| ▸ | TUBA4A | P68366 | 1/20 | 0.41 |
| ▸ | TUBB4B | P68371 | 1/20 | 0.41 |
| ▸ | TUBB3 | Q13509 | 1/20 | 0.41 |
| ▸ | TUBB2A | Q13885 | 1/20 | 0.41 |
| ▸ | TUBB8 | Q3ZCM7 | 1/20 | 0.41 |
| ▸ | TUBA3E | Q6PEY2 | 1/20 | 0.41 |
| ▸ | TUBA1A | Q71U36 | 1/20 | 0.41 |
| ▸ | TUBA1C | Q9BQE3 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL17268775 | 0.86 | NPC1 (0.72) | NPC1RAB9AKMT2ATDP1IKBKB | |
| SCHEMBL5788555 | 0.81 | MAP3K8 (0.44) | NPC1RAB9AKMT2ATDP1IKBKB | |
| SCHEMBL5475238 | 0.79 | NPC1 (0.58) | NPC1RAB9AKMT2ATDP1IKBKB | |
| SCHEMBL2879120 | 0.79 | NPC1 (0.67) | NPC1RAB9AKMT2ATDP1IKBKB | |
| SCHEMBL3979017 | 0.79 | NPC1 (0.67) | NPC1RAB9AKMT2ATDP1IKBKB | |
| SCHEMBL5789265 | 0.77 | TYK2 (0.51) | NPC1RAB9AIKBKBTYK2EGFR | |
| SCHEMBL15504606 | 0.76 | RAB9A (0.68) | NPC1RAB9AKMT2ATDP1IKBKB | |
| SCHEMBL15703517 | 0.76 | NPC1 (1.00) | NPC1RAB9AKMT2ATDP1IKBKB | |
| SCHEMBL4798991 | 0.75 | KMT2A (0.50) | NPC1RAB9AKMT2ATDP1IKBKB | |
| SCHEMBL5641499 | 0.75 | NPC1 (0.58) | NPC1RAB9AKMT2ATDP1IKBKB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20060276489-A1 | Inhibitors of Tubulin Polymerization | RIGEL PHARMACEUTICALS, INC. (US) | 2006-12-07 | — | — | US | disclosed |
| US-7071190-B2 | Inhibitors to tubulin polymerization | RIGEL PHARMACEUTICALS, INC. (US) | 2006-07-04 | — | — | US | disclosed |
| EP-1480645-A4 | INHIBITORS OF TUBULIN POLYMERIZATION | RIGEL PHARMACEUTICALS INC (US) | 2006-03-29 | — | — | EP | disclosed |
| EP-1480645-A1 | INHIBITORS OF TUBULIN POLYMERIZATION | Rigel Pharmaceuticals, Inc. (US) | 2004-12-01 | — | — | EP | disclosed |
| US-20030225112-A1 | Inhibitors to tubulin polymerization | RIGEL PHARMACEUTICALS, INC. | 2003-12-04 | — | — | US | disclosed |
| WO-2003070241-A1 | INHIBITORS OF TUBULIN POLYMERIZATION | RIGEL PHARMACEUTICALS, INC. (US) | 2003-08-28 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20030225112-A1 | Inhibitors to tubulin polymerization | TUBB3, TUBB1, TUBB | NPC1 687/4885RAB9A 1690/4885KMT2A 1795/4885 |
| US-20060276489-A1 | Inhibitors of Tubulin Polymerization | TUBB3, TUBB1, TUBB | NPC1 725/4885RAB9A 1778/4885KMT2A 1791/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.