Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.44 |
| ▸ | MAPT | P10636 | 3/20 | 0.44 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.44 |
| ▸ | RAB9A | P51151 | 2/20 | 0.44 |
| ▸ | NPC1 | O15118 | 1/20 | 0.44 |
| ▸ | XBP1 | P17861 | 1/20 | 0.44 |
| ▸ | KLF5 | Q13887 | 1/20 | 0.44 |
| ▸ | METAP1 | P53582 | 1/20 | 0.43 |
| ▸ | TGFBR1 | P36897 | 2/20 | 0.42 |
| ▸ | PLK4 | O00444 | 1/20 | 0.42 |
| ▸ | CHEK1 | O14757 | 1/20 | 0.42 |
| ▸ | PRKD3 | O94806 | 1/20 | 0.42 |
| ▸ | LCK | P06239 | 1/20 | 0.42 |
| ▸ | CSF1R | P07333 | 1/20 | 0.42 |
| ▸ | ROS1 | P08922 | 1/20 | 0.42 |
| ▸ | KIT | P10721 | 1/20 | 0.42 |
| ▸ | FGFR1 | P11362 | 1/20 | 0.42 |
| ▸ | SRC | P12931 | 1/20 | 0.42 |
| ▸ | FLT1 | P17948 | 1/20 | 0.42 |
| ▸ | FGFR3 | P22607 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5789755 | 0.89 | MAPT (0.47) | KDM4EMAPTSMN1; SMN2RAB9ANPC1 | |
| SCHEMBL5787031 | 0.81 | GAA (0.48) | KDM4EMAPTSMN1; SMN2RAB9ANPC1 | |
| SCHEMBL5788291 | 0.81 | MAPT (0.48) | KDM4EMAPTSMN1; SMN2RAB9ANPC1 | |
| SCHEMBL5790886 | 0.81 | USP7 (0.48) | KDM4EMAPTSMN1; SMN2RAB9ANPC1 | |
| SCHEMBL5789465 | 0.81 | NPC1 (0.51) | KDM4EMAPTSMN1; SMN2RAB9ANPC1 | |
| SCHEMBL25767630 | 0.80 | PTGS2 (0.49) | KDM4EMAPTSMN1; SMN2TGFBR1CDK2 | |
| SCHEMBL5790985 | 0.79 | TGFBR1 (0.59) | KDM4EMAPTSMN1; SMN2TGFBR1KDR | |
| SCHEMBL5787865 | 0.79 | BRD4 (0.46) | KDM4EMAPTSMN1; SMN2RAB9ANPC1 | |
| SCHEMBL5790871 | 0.79 | PTGS2 (0.44) | KDM4EMAPTSMN1; SMN2RAB9ANPC1 | |
| SCHEMBL5788058 | 0.78 | TGFBR1 (0.57) | KDM4ETGFBR1GAA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 9 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1543003-B1 | IMIDAZO¬1,2-A|PYRIDINES | SMITHKLINE BEECHAM CORP (US) | 2006-05-17 | — | — | EP | claimed |
| US-20050234029-A1 | Compounds | DODIC NERINA | 2005-10-20 | — | — | US | claimed |
| EP-1543003-A2 | IMIDAZO[1,2-A]PYRIDINES | SMITHKLINE BEECHAM CORPORATION (US) | 2005-06-22 | — | — | EP | claimed |
| WO-2004013138-A2 | IMIDAZO`1,2-A!PYRIDINES | SMITHKLINE BEECHAM CORPORATION (US) | 2004-02-12 | — | — | WO | claimed |
| EP-1543003-B1 | IMIDAZO¬1,2-A|PYRIDINES | SMITHKLINE BEECHAM CORP (US) | 2006-05-17 | — | — | EP | disclosed |
| US-20050245520-A1 | 2-Phenylpyridin-4-yl derivatives as alk5 inhibitors | DODIC NERINA | 2005-11-03 | — | — | US | disclosed |
| US-20050234029-A1 | Compounds | DODIC NERINA | 2005-10-20 | — | — | US | disclosed |
| EP-1543003-A2 | IMIDAZO[1,2-A]PYRIDINES | SMITHKLINE BEECHAM CORPORATION (US) | 2005-06-22 | — | — | EP | disclosed |
| WO-2004013138-A2 | IMIDAZO`1,2-A!PYRIDINES | SMITHKLINE BEECHAM CORPORATION (US) | 2004-02-12 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20050245520-A1 | 2-Phenylpyridin-4-yl derivatives as alk5 inhibitors | SMAD2, SMAD3, ALK | KDM4E 514/4885MAPT 1496/4885SMN1; SMN2 2815/4885 |
| US-20050234029-A1 | Compounds | SMAD3, SMAD2, ACVR1 | KDM4E 1041/4885MAPT 1376/4885SMN1; SMN2 2595/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.