Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | POLB | P06746 | 2/20 | 0.44 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.44 |
| ▸ | LMNA | P02545 | 3/20 | 0.41 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.41 |
| ▸ | GAA | P10253 | 1/20 | 0.41 |
| ▸ | MAPT | P10636 | 3/20 | 0.40 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.40 |
| ▸ | MITF | O75030 | 1/20 | 0.39 |
| ▸ | TSHR | P16473 | 1/20 | 0.38 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.38 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.38 |
| ▸ | NPC1 | O15118 | 2/20 | 0.37 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.37 |
| ▸ | BLM | P54132 | 1/20 | 0.37 |
| ▸ | PMP22 | Q01453 | 1/20 | 0.37 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.36 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.36 |
| ▸ | CTDSP1 | Q9GZU7 | 1/20 | 0.36 |
| ▸ | MEN1 | O00255 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6571203 | 0.81 | MAPT (0.54) | POLBALDH1A1LMNAL3MBTL1GAA | |
| SCHEMBL5792626 | 0.81 | TSHR (0.48) | POLBALDH1A1LMNAL3MBTL1GAA | |
| SCHEMBL3788027 | 0.77 | MAPT (0.48) | POLBALDH1A1LMNAGAAMAPT | |
| SCHEMBL1625522 | 0.77 | KMT2A (0.51) | POLBALDH1A1LMNAL3MBTL1GAA | |
| SCHEMBL8773146 | 0.76 | TSHR (0.51) | POLBALDH1A1L3MBTL1GAAMAPT | |
| SCHEMBL607557 | 0.76 | ALDH1A1 (0.65) | POLBALDH1A1LMNAL3MBTL1GAA | |
| SCHEMBL31729425 | 0.76 | ALDH1A1 (0.52) | ALDH1A1LMNAMAPTSMN1; SMN2MITF | |
| SCHEMBL3435480 | 0.76 | MAPT (0.48) | POLBALDH1A1LMNAGAAMAPT | |
| SCHEMBL28086239 | 0.76 | ALDH1A1 (0.52) | ALDH1A1LMNAMAPTSMN1; SMN2MITF | |
| SCHEMBL30682787 | 0.75 | TSHR (0.43) | POLBALDH1A1LMNAL3MBTL1MAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1646610-A1 | TETRAHYDROCARBAZOLE DERIVATIVES AND THEIR PHARMACEUTICAL USE | SmithKline Beecham Corporation (US) | 2006-04-19 | — | — | EP | disclosed |
| WO-2005005386-A1 | TETRAHYDROCARBAZOLE DERIVATIVES AND THEIR PHARMACEUTICAL USE | SMITHKLINE BEECHAM CORPORATION (US) | 2005-01-20 | — | — | WO | disclosed |