Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NPC1 | O15118 | 3/20 | 0.47 |
| ▸ | RAB9A | P51151 | 3/20 | 0.47 |
| ▸ | USP7 | Q93009 | 1/20 | 0.47 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.45 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.45 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.45 |
| ▸ | TGFBR1 | P36897 | 9/20 | 0.45 |
| ▸ | MAPK14 | Q16539 | 4/20 | 0.44 |
| ▸ | TUBB4A | P04350 | 2/20 | 0.44 |
| ▸ | TUBB | P07437 | 2/20 | 0.44 |
| ▸ | TUBA3C | P0DPH7 | 2/20 | 0.44 |
| ▸ | TUBA1B | P68363 | 2/20 | 0.44 |
| ▸ | TUBA4A | P68366 | 2/20 | 0.44 |
| ▸ | TUBB4B | P68371 | 2/20 | 0.44 |
| ▸ | TUBB3 | Q13509 | 2/20 | 0.44 |
| ▸ | TUBB2A | Q13885 | 2/20 | 0.44 |
| ▸ | TUBB8 | Q3ZCM7 | 2/20 | 0.44 |
| ▸ | TUBA3E | Q6PEY2 | 2/20 | 0.44 |
| ▸ | TUBA1A | Q71U36 | 2/20 | 0.44 |
| ▸ | TUBA1C | Q9BQE3 | 2/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5789465 | 0.90 | NPC1 (0.51) | NPC1RAB9AUSP7KDM4EALDH1A1 | |
| SCHEMBL6364773 | 0.89 | TGFBR1 (0.42) | NPC1RAB9AKDM4EALDH1A1TGFBR1 | |
| SCHEMBL5792573 | 0.88 | TGFBR1 (0.45) | USP7TGFBR1MAPK14KDR | |
| SCHEMBL5789474 | 0.88 | CDK4 (0.46) | SMN1; SMN2TGFBR1MAPK14KDR | |
| SCHEMBL5791222 | 0.88 | TGFBR1 (0.40) | NPC1RAB9AKDM4EALDH1A1SMN1; SMN2 | |
| SCHEMBL5786433 | 0.86 | TGFBR1 (0.47) | TGFBR1MAPK14KDR | |
| SCHEMBL5791351 | 0.85 | TGFBR1 (0.44) | NPC1RAB9AALDH1A1TGFBR1MAPK14 | |
| SCHEMBL6372080 | 0.84 | TGFBR1 (0.51) | TGFBR1MAPK14KDR | |
| SCHEMBL5787144 | 0.84 | TGFBR1 (0.60) | TGFBR1MAPK14KDRNR1I3 | |
| SCHEMBL5805807 | 0.84 | KDM4E (0.40) | RAB9AKDM4ETGFBR1MAPK14KDR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1543003-B1 | IMIDAZO¬1,2-A|PYRIDINES | SMITHKLINE BEECHAM CORP (US) | 2006-05-17 | — | — | EP | disclosed |
| US-20050234029-A1 | Compounds | DODIC NERINA | 2005-10-20 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20050234029-A1 | Compounds | SMAD3, SMAD2, ACVR1 | NPC1 3139/4885RAB9A 3703/4885USP7 4477/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.