Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TGFBR1 | P36897 | 14/20 | 0.42 |
| ▸ | KDR | P35968 | 4/20 | 0.41 |
| ▸ | MAPK14 | Q16539 | 4/20 | 0.41 |
| ▸ | CLK2 | P49760 | 1/20 | 0.40 |
| ▸ | DYRK1A | Q13627 | 1/20 | 0.40 |
| ▸ | HASPIN | Q8TF76 | 1/20 | 0.40 |
| ▸ | HTR6 | P50406 | 1/20 | 0.39 |
| ▸ | SCN5A | Q14524 | 1/20 | 0.39 |
| ▸ | MAT2A | P31153 | 1/20 | 0.38 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.38 |
| ▸ | NPC1 | O15118 | 1/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.38 |
| ▸ | GAA | P10253 | 1/20 | 0.38 |
| ▸ | MAPT | P10636 | 1/20 | 0.38 |
| ▸ | RAB9A | P51151 | 1/20 | 0.38 |
| ▸ | SCN10A | Q9Y5Y9 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5789426 | 0.89 | NPC1 (0.47) | TGFBR1KDRMAPK14KDM4ENPC1 | |
| SCHEMBL5792573 | 0.84 | TGFBR1 (0.45) | TGFBR1KDRMAPK14DYRK1A | |
| SCHEMBL5789474 | 0.84 | CDK4 (0.46) | TGFBR1KDRMAPK14GAAMAPT | |
| SCHEMBL5791222 | 0.84 | TGFBR1 (0.40) | TGFBR1KDRMAPK14KDM4ENPC1 | |
| SCHEMBL5786433 | 0.83 | TGFBR1 (0.47) | TGFBR1KDRMAPK14 | |
| SCHEMBL5791351 | 0.82 | TGFBR1 (0.44) | TGFBR1KDRMAPK14NPC1ALDH1A1 | |
| SCHEMBL6324466 | 0.81 | TGFBR1 (0.43) | TGFBR1KDRMAPK14 | |
| SCHEMBL5787144 | 0.81 | TGFBR1 (0.60) | TGFBR1KDRMAPK14 | |
| SCHEMBL6372080 | 0.81 | TGFBR1 (0.51) | TGFBR1KDRMAPK14 | |
| SCHEMBL5805807 | 0.81 | KDM4E (0.40) | TGFBR1KDRMAPK14KDM4EGAA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20050234029-A1 | Compounds | DODIC NERINA | 2005-10-20 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20050234029-A1 | Compounds | SMAD3, SMAD2, ACVR1 | TGFBR1 4/4885KDR 160/4885MAPK14 285/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.