Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 6/20 | 0.47 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.47 |
| ▸ | HPGD | P15428 | 2/20 | 0.47 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.47 |
| ▸ | TSHR | P16473 | 2/20 | 0.47 |
| ▸ | ESR1 | P03372 | 1/20 | 0.47 |
| ▸ | ITGB3 | P05106 | 1/20 | 0.47 |
| ▸ | ITGA2B | P08514 | 1/20 | 0.47 |
| ▸ | HMGB1 | P09429 | 1/20 | 0.47 |
| ▸ | GGT1 | P19440 | 1/20 | 0.47 |
| ▸ | PTGS1 | P23219 | 1/20 | 0.47 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.47 |
| ▸ | BLM | P54132 | 1/20 | 0.47 |
| ▸ | NAPRT | Q6XQN6 | 1/20 | 0.47 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.47 |
| ▸ | IKBKB | O14920 | 1/20 | 0.44 |
| ▸ | NPC1 | O15118 | 1/20 | 0.43 |
| ▸ | RAB9A | P51151 | 1/20 | 0.43 |
| ▸ | GAA | P10253 | 2/20 | 0.43 |
| ▸ | LMNA | P02545 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3715949 | 0.84 | KDM4E (0.56) | KDM4EALDH1A1HPGDHSD17B10TSHR | |
| SCHEMBL31423348 | 0.84 | KDM4E (0.56) | KDM4EALDH1A1HPGDHSD17B10TSHR | |
| SCHEMBL4228872 | 0.80 | KDM4E (0.61) | KDM4EALDH1A1HPGDHSD17B10TSHR | |
| SCHEMBL1462677 | 0.79 | ALDH1A1 (0.47) | KDM4EALDH1A1HPGDTDP1IKBKB | |
| SCHEMBL5785101 | 0.78 | KDM4E (0.51) | KDM4EALDH1A1HPGDHSD17B10TSHR | |
| SCHEMBL1902570 | 0.77 | LMNA (0.47) | KDM4EALDH1A1HPGDHSD17B10TSHR | |
| SCHEMBL1902327 | 0.77 | KDM4E (0.51) | KDM4EALDH1A1HPGDHSD17B10TSHR | |
| SCHEMBL5789220 | 0.77 | ALDH1A1 (0.62) | KDM4EALDH1A1HPGDHSD17B10TSHR | |
| SCHEMBL12386822 | 0.77 | MEN1 (0.47) | KDM4EALDH1A1HPGDTDP1CYP1A2 | |
| SCHEMBL17584292 | 0.76 | ALDH1A1 (0.48) | KDM4EALDH1A1HPGDHSD17B10TSHR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1507778-A4 | ANTI-TUMOUR POLYCYCLIC CARBOXAMIDES | UNIV TROBE (AU) | 2006-05-31 | — | — | EP | disclosed |
| EP-1507778-A1 | ANTI-TUMOUR POLYCYCLIC CARBOXAMIDES | LA TROBE UNIVERSITY (AU) | 2005-02-23 | — | — | EP | disclosed |
| WO-2003097642-A1 | ANTI-TUMOUR POLYCYCLIC CARBOXAMIDES | LA TROBE UNIVERSITY (AU) | 2003-11-27 | — | — | WO | disclosed |