Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP1A2 | P05177 | 1/20 | 0.35 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.35 |
| ▸ | MAOB | P27338 | 1/20 | 0.33 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.33 |
| ▸ | HPGD | P15428 | 1/20 | 0.33 |
| ▸ | LTA4H | P09960 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4079655 | 0.88 | LTA4H (0.38) | MAOBHRH3LTA4H | |
| SCHEMBL4088693 | 0.88 | LTA4H (0.38) | MAOBHRH3LTA4H | |
| SCHEMBL8237729 | 0.88 | LTA4H (0.38) | MAOBHRH3LTA4H | |
| SCHEMBL4084781 | 0.79 | OPRM1 (0.33) | HRH3 | |
| SCHEMBL12371257 | 0.79 | OPRM1 (0.33) | HRH3 | |
| SCHEMBL10867797 | 0.77 | ACHE (0.45) | HPGD | |
| SCHEMBL4089546 | 0.75 | HRH3 (0.40) | MAOBHRH3 | |
| SCHEMBL4089544 | 0.75 | HRH3 (0.40) | MAOBHRH3 | |
| SCHEMBL10469227 | 0.74 | HRH3 (0.39) | MAOBHRH3 | |
| Iodide SCHEMBL5786537 | 0.72 | HRH3 (0.41) | MAOBHRH3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1692128-A1 | INDAZOLE COMPOUNDS AND METHODS OF USE THEREOF AS PROTEIN KINASE INHIBITORS | Signal Pharmaceuticals LLC (US) | 2006-08-23 | — | — | EP | disclosed |
| WO-2005051942-A1 | INDAZOLE COMPOUNDS AND METHODS OF USE THEREOF AS PROTEIN KINASE INHIBITORS | SIGNAL PHARMACEUTICALS, LLC (US) | 2005-06-09 | — | — | WO | disclosed |