Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | POLB | P06746 | 2/20 | 0.41 |
| ▸ | NR3C1 | P04150 | 1/20 | 0.40 |
| ▸ | CTSL | P07711 | 1/20 | 0.40 |
| ▸ | CTSS | P25774 | 1/20 | 0.40 |
| ▸ | CTSK | P43235 | 1/20 | 0.40 |
| ▸ | PTGES2 | Q9H7Z7 | 1/20 | 0.39 |
| ▸ | TAAR1 | Q96RJ0 | 3/20 | 0.39 |
| ▸ | SLC18A2 | Q05940 | 1/20 | 0.39 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.39 |
| ▸ | PLG | P00747 | 1/20 | 0.39 |
| ▸ | PLAU | P00749 | 1/20 | 0.39 |
| ▸ | PLAT | P00750 | 1/20 | 0.39 |
| ▸ | CTSC | P53634 | 3/20 | 0.39 |
| ▸ | MEN1 | O00255 | 1/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.39 |
| ▸ | NPC1 | O15118 | 1/20 | 0.39 |
| ▸ | RAB9A | P51151 | 1/20 | 0.39 |
| ▸ | CA2 | P00918 | 1/20 | 0.38 |
| ▸ | CA7 | P43166 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2917309 | 1.00 | POLB (0.41) | POLBNR3C1CTSLCTSSCTSK | |
| SCHEMBL2917307 | 1.00 | POLB (0.41) | POLBNR3C1CTSLCTSSCTSK | |
| SCHEMBL7372550 | 0.85 | MEN1 (0.41) | CTSLCTSSCTSKPTGES2TAAR1 | |
| SCHEMBL7085022 | 0.81 | CA1 (0.49) | CTSCMEN1KMT2ACA2 | |
| SCHEMBL4541620 | 0.79 | CA2 (0.61) | POLBCTSLCTSSCTSKMEN1 | |
| SCHEMBL4541622 | 0.79 | CA2 (0.61) | POLBCTSLCTSSCTSKMEN1 | |
| SCHEMBL1310109 | 0.78 | TAAR1 (0.53) | TAAR1SLC18A2SIGMAR1CTSCMEN1 | |
| SCHEMBL6852331 | 0.78 | TAAR1 (0.53) | TAAR1SLC18A2SIGMAR1CTSCMEN1 | |
| SCHEMBL1086155 | 0.78 | TAAR1 (0.53) | TAAR1SLC18A2SIGMAR1CTSCMEN1 | |
| SCHEMBL12204083 | 0.77 | SIGMAR1 (0.57) | TAAR1SLC18A2SIGMAR1MEN1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 8 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2006014253-A2 | FACTOR VIIA VARIANTS | GENENTECH, INC. (US) | 2006-02-09 | — | — | WO | disclosed |
| EP-0772590-B1 | THROMBIN INHIBITORS | MERCK & CO INC (US) | 2002-10-09 | — | — | EP | disclosed |
| US-5744487-A | PROTEASE INHIBITORS | MITSUBISHI CHEMICAL CORPORATION (JP) | 1998-04-28 | — | — | US | disclosed |
| US-5741799-A | ANTICOAGULANTS OF SULFONAMIDO HETEROCYCLIC THROMBIN INHIBITORS | BRISTOL-MYERS SQUIBB COMPANY (US) | 1998-04-21 | — | — | US | disclosed |
| US-5741792-A | ANTICOAGULANTS OF SULFONAMIDO HETEROCYCLIC THROMBIN INHIBITORS | BRISTOL-MYERS SQUIBB COMPANY (US) | 1998-04-21 | — | — | US | disclosed |
| US-5714485-A | Piperidine and hexahydropyridazine thrombin inhibitors | MERCK & CO., INC. (US) | 1998-02-03 | — | — | US | disclosed |
| US-5510369-A | ANTICOAGULANTS | MERCK & CO., INC. (US) | 1996-04-23 | — | — | US | disclosed |
| EP-0669317-A1 | Prolineamide derivatives | Mitsubishi Chemical Corporation (JP) | 1995-08-30 | — | — | EP | disclosed |