Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.40 |
| ▸ | ELANE | P08246 | 5/20 | 0.39 |
| ▸ | P2RX7 | Q99572 | 2/20 | 0.33 |
| ▸ | PARP1 | P09874 | 1/20 | 0.33 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.33 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.33 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.33 |
| ▸ | LMNA | P02545 | 2/20 | 0.33 |
| ▸ | HIF1A | Q16665 | 2/20 | 0.33 |
| ▸ | PDE2A | O00408 | 1/20 | 0.33 |
| ▸ | PDE6D | O43924 | 1/20 | 0.33 |
| ▸ | PDE6A | P16499 | 1/20 | 0.33 |
| ▸ | PDE6G | P18545 | 1/20 | 0.33 |
| ▸ | PDE4A | P27815 | 1/20 | 0.33 |
| ▸ | PDE6B | P35913 | 1/20 | 0.33 |
| ▸ | PDE6C | P51160 | 1/20 | 0.33 |
| ▸ | PDE4B | Q07343 | 1/20 | 0.33 |
| ▸ | PDE4C | Q08493 | 1/20 | 0.33 |
| ▸ | PDE4D | Q08499 | 1/20 | 0.33 |
| ▸ | PDE6H | Q13956 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3974206 | 0.68 | SMN1; SMN2 (0.44) | SMN1; SMN2ALDH1A1KDM4ELMNAPDE2A | |
| SCHEMBL29150251 | 0.64 | ELANE (0.49) | SMN1; SMN2ELANEALDH1A1KDM4EKMT2A | |
| SCHEMBL11076238 | 0.61 | TDP2 (0.45) | SMN1; SMN2ALDH1A1KDM4EKMT2ATP53 | |
| SCHEMBL10439112 | 0.60 | SMN1; SMN2 (0.47) | SMN1; SMN2ELANEALDH1A1KDM4EKMT2A | |
| SCHEMBL149479 | 0.60 | ALDH1A1 (0.68) | SMN1; SMN2ALDH1A1KDM4EKMT2ALMNA | |
| SCHEMBL5775044 | 0.59 | ALDH1A1 (0.38) | SMN1; SMN2ELANEPARP1ALDH1A1KDM4E | |
| Hydrochloric Acid SCHEMBL31716024 | 0.59 | ALDH1A1 (0.66) | SMN1; SMN2ALDH1A1KDM4EKMT2ALMNA | |
| Hydrochloric Acid SCHEMBL15709616 | 0.59 | ALDH1A1 (0.66) | SMN1; SMN2ALDH1A1KDM4EKMT2ALMNA | |
| SCHEMBL18317487 | 0.59 | SMN1; SMN2 (0.60) | SMN1; SMN2ALDH1A1KDM4EKMT2ABACE1 | |
| SCHEMBL366928 | 0.58 | IDO1 (0.45) | SMN1; SMN2ALDH1A1KMT2ALMNAHIF1A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1644369-A2 | ARYLAMINE-SUBSTITUTED QUINAZOLINONE COMPOUNDS | F. HOFFMANN-LA ROCHE AG (CH) | 2006-04-12 | — | — | EP | disclosed |
| WO-2005005395-A2 | ARYLAMINE-SUBSTITUTED QUINAZOLINONE COMPOUNDS | F. HOFFMANN-LA ROCHE AG (CH) | 2005-01-20 | — | — | WO | disclosed |