Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 7/20 | 0.51 |
| ▸ | HTT | P42858 | 5/20 | 0.51 |
| ▸ | KDM4E | B2RXH2 | 5/20 | 0.51 |
| ▸ | SMN1; SMN2 | Q16637 | 7/20 | 0.50 |
| ▸ | LMNA | P02545 | 5/20 | 0.50 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.50 |
| ▸ | HPGD | P15428 | 4/20 | 0.50 |
| ▸ | TDP1 | Q9NUW8 | 3/20 | 0.50 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.50 |
| ▸ | PKM | P14618 | 1/20 | 0.50 |
| ▸ | BTK | Q06187 | 1/20 | 0.41 |
| ▸ | NPC1 | O15118 | 3/20 | 0.40 |
| ▸ | RAB9A | P51151 | 3/20 | 0.40 |
| ▸ | POLB | P06746 | 1/20 | 0.40 |
| ▸ | CNR2 | P34972 | 1/20 | 0.39 |
| ▸ | MEN1 | O00255 | 3/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.39 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.39 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.39 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2368945 | 0.77 | MAPT (0.53) | MAPTHTTKDM4ESMN1; SMN2LMNA | |
| SCHEMBL2369510 | 0.76 | SMN1; SMN2 (0.52) | MAPTHTTKDM4ESMN1; SMN2LMNA | |
| SCHEMBL2369061 | 0.75 | FGFR1 (0.50) | HTTKDM4ESMN1; SMN2LMNAHPGD | |
| SCHEMBL2369522 | 0.72 | MAPT (0.38) | MAPTHTTKDM4ESMN1; SMN2LMNA | |
| SCHEMBL5788742 | 0.72 | MAPT (0.56) | MAPTHTTLMNAALDH1A1HPGD | |
| SCHEMBL5803878 | 0.71 | HTT (0.47) | MAPTHTTKDM4ESMN1; SMN2LMNA | |
| SCHEMBL2368757 | 0.69 | LMNA (0.47) | MAPTHTTSMN1; SMN2LMNAALDH1A1 | |
| SCHEMBL5791688 | 0.69 | LMNA (0.52) | MAPTHTTKDM4ESMN1; SMN2LMNA | |
| SCHEMBL27909495 | 0.68 | STK17B (0.51) | MAPTKDM4ESMN1; SMN2ALDH1A1HPGD | |
| SCHEMBL2368088 | 0.66 | HTT (0.45) | MAPTHTTSMN1; SMN2BTKKMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1641803-A1 | THIENOPYRIMIDINE DERIVATIVES AS POTASSIUM CHANNEL INHIBITORS | Xention Discovery Limited (GB) | 2006-04-05 | — | — | EP | disclosed |
| WO-2004111057-A1 | THIENOPYRIMIDINE DERIVATIVES AS POTASSIUM CHANNEL INHIBITORS | XENTION DISCOVERY LIMITED (GB) | 2004-12-23 | — | — | WO | disclosed |