Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | FGFR1 | P11362 | 5/20 | 0.50 |
| ▸ | DAPK3 | O43293 | 1/20 | 0.50 |
| ▸ | PRKD3 | O94806 | 1/20 | 0.50 |
| ▸ | MAP4K4 | O95819 | 1/20 | 0.50 |
| ▸ | ABL1 | P00519 | 1/20 | 0.50 |
| ▸ | NTRK1 | P04629 | 1/20 | 0.50 |
| ▸ | LCK | P06239 | 1/20 | 0.50 |
| ▸ | CSF1R | P07333 | 1/20 | 0.50 |
| ▸ | RET | P07949 | 1/20 | 0.50 |
| ▸ | MET | P08581 | 1/20 | 0.50 |
| ▸ | PDGFRB | P09619 | 1/20 | 0.50 |
| ▸ | PDGFRA | P16234 | 1/20 | 0.50 |
| ▸ | PRKACA | P17612 | 1/20 | 0.50 |
| ▸ | FLT1 | P17948 | 1/20 | 0.50 |
| ▸ | LTK | P29376 | 1/20 | 0.50 |
| ▸ | KDR | P35968 | 1/20 | 0.50 |
| ▸ | MAP2K2 | P36507 | 1/20 | 0.50 |
| ▸ | MAPK8 | P45983 | 1/20 | 0.50 |
| ▸ | MAPK9 | P45984 | 1/20 | 0.50 |
| ▸ | CSNK1A1 | P48729 | 1/20 | 0.50 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2369844 | 0.84 | SMN1; SMN2 (0.52) | FGFR1DAPK3PRKD3MAP4K4ABL1 | |
| SCHEMBL2369510 | 0.84 | SMN1; SMN2 (0.52) | FGFR1LMNACSNK2A2CSNK2BCSNK2A1 | |
| SCHEMBL2368088 | 0.82 | HTT (0.45) | FGFR1DAPK3PRKD3MAP4K4ABL1 | |
| SCHEMBL2368766 | 0.82 | MITF (0.44) | FGFR1DAPK3PRKD3MAP4K4ABL1 | |
| SCHEMBL5788742 | 0.80 | MAPT (0.56) | FGFR1LMNAMAPK1HPGDHTT | |
| SCHEMBL2369522 | 0.80 | MAPT (0.38) | FGFR1DAPK3PRKD3MAP4K4ABL1 | |
| SCHEMBL2368559 | 0.78 | CHEK1 (0.43) | LMNAMAPK1TSHRSMN1; SMN2HPGD | |
| SCHEMBL5791585 | 0.75 | MAPT (0.51) | BTKLMNAMAPK1TSHRSMN1; SMN2 | |
| SCHEMBL6364382 | 0.71 | ESR1 (0.45) | FGFR1DAPK3PRKD3MAP4K4ABL1 | |
| SCHEMBL14964882 | 0.69 | FGFR1 (0.53) | FGFR1DAPK3PRKD3MAP4K4ABL1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8022076-B2 | Thieno[2,3-d]pyrimidine derivatives as potassium channel modulators; antiarrhythmia agents | XENTION LIMITED (GB) | 2011-09-20 | — | — | US | disclosed |