Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTT | P42858 | 3/20 | 0.45 |
| ▸ | PIP4K2C | Q8TBX8 | 2/20 | 0.45 |
| ▸ | CYP19A1 | P11511 | 1/20 | 0.38 |
| ▸ | DHFR | P00374 | 1/20 | 0.38 |
| ▸ | MAPT | P10636 | 1/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.38 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.38 |
| ▸ | KDR | P35968 | 2/20 | 0.37 |
| ▸ | IDO1 | P14902 | 1/20 | 0.37 |
| ▸ | TDO2 | P48775 | 1/20 | 0.35 |
| ▸ | BRD4 | O60885 | 1/20 | 0.35 |
| ▸ | NUDT1 | P36639 | 2/20 | 0.35 |
| ▸ | ADORA2A | P29274 | 1/20 | 0.35 |
| ▸ | ADORA1 | P30542 | 1/20 | 0.35 |
| ▸ | CHEK1 | O14757 | 1/20 | 0.35 |
| ▸ | FGFR1 | P11362 | 2/20 | 0.35 |
| ▸ | PAX8 | Q06710 | 1/20 | 0.35 |
| ▸ | DAPK3 | O43293 | 1/20 | 0.35 |
| ▸ | PRKD3 | O94806 | 1/20 | 0.35 |
| ▸ | MAP4K4 | O95819 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2368766 | 0.83 | MITF (0.44) | HTTPIP4K2CMAPTKMT2ASMN1; SMN2 | |
| SCHEMBL2368956 | 0.82 | HTT (0.55) | HTTPIP4K2CMAPTKMT2ASMN1; SMN2 | |
| SCHEMBL2369061 | 0.82 | FGFR1 (0.50) | HTTSMN1; SMN2KDRFGFR1DAPK3 | |
| SCHEMBL2368453 | 0.80 | PKM (0.51) | HTTPIP4K2CCYP19A1MAPTSMN1; SMN2 | |
| SCHEMBL5790076 | 0.79 | SMN1; SMN2 (0.37) | HTTMAPTKMT2ASMN1; SMN2KDR | |
| SCHEMBL2369510 | 0.74 | SMN1; SMN2 (0.52) | HTTPIP4K2CMAPTKMT2ASMN1; SMN2 | |
| SCHEMBL2369844 | 0.74 | SMN1; SMN2 (0.52) | HTTPIP4K2CMAPTKMT2ASMN1; SMN2 | |
| SCHEMBL4481360 | 0.72 | KDR (0.69) | HTTPIP4K2CDHFRMAPTKMT2A | |
| SCHEMBL2368559 | 0.71 | CHEK1 (0.43) | HTTPIP4K2CMAPTKMT2ASMN1; SMN2 | |
| SCHEMBL2369522 | 0.70 | MAPT (0.38) | HTTMAPTKMT2ASMN1; SMN2KDR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8022076-B2 | Thieno[2,3-d]pyrimidine derivatives as potassium channel modulators; antiarrhythmia agents | XENTION LIMITED (GB) | 2011-09-20 | — | — | US | disclosed |
| US-20050026935-A1 | Compounds | XENTION DISCOVERY LTD. | 2005-02-03 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20050026935-A1 | Compounds | KCNJ11, KCNJ1, KCNH1 | HTT 543/4885PIP4K2C 2695/4885CYP19A1 512/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.