Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ADORA3 | P0DMS8 | 2/20 | 0.49 |
| ▸ | MASP2 | O00187 | 1/20 | 0.47 |
| ▸ | F2 | P00734 | 1/20 | 0.47 |
| ▸ | MAPT | P10636 | 5/20 | 0.43 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.43 |
| ▸ | NPC1 | O15118 | 2/20 | 0.43 |
| ▸ | RAB9A | P51151 | 2/20 | 0.43 |
| ▸ | SCD | O00767 | 1/20 | 0.43 |
| ▸ | NR1H4 | Q96RI1 | 1/20 | 0.42 |
| ▸ | LMNA | P02545 | 3/20 | 0.42 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.42 |
| ▸ | GAA | P10253 | 2/20 | 0.42 |
| ▸ | CTSK | P43235 | 1/20 | 0.42 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.41 |
| ▸ | HTT | P42858 | 1/20 | 0.41 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.41 |
| ▸ | PARP1 | P09874 | 1/20 | 0.40 |
| ▸ | APP | P05067 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL445219 | 1.00 | ADORA3 (0.49) | ADORA3MASP2F2MAPTSMN1; SMN2 | |
| SCHEMBL442928 | 0.82 | MASP2 (0.50) | ADORA3MASP2F2MAPTSMN1; SMN2 | |
| SCHEMBL442927 | 0.82 | MASP2 (0.50) | ADORA3MASP2F2MAPTSMN1; SMN2 | |
| SCHEMBL447511 | 0.82 | MASP2 (0.50) | ADORA3MASP2F2MAPTSMN1; SMN2 | |
| SCHEMBL443730 | 0.82 | TAS1R3 (0.50) | SMN1; SMN2NPC1RAB9ALMNAALDH1A1 | |
| SCHEMBL445220 | 0.80 | ADORA3 (0.49) | ADORA3MASP2F2MAPTSMN1; SMN2 | |
| SCHEMBL442961 | 0.77 | HDAC1 (0.51) | — | |
| SCHEMBL445574 | 0.76 | MEN1 (0.49) | SMN1; SMN2NPC1RAB9ALMNAKDM4E | |
| SCHEMBL5791272 | 0.76 | MEN1 (0.49) | SMN1; SMN2NPC1RAB9ALMNAKDM4E | |
| SCHEMBL442422 | 0.76 | POLB (0.53) | ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1611088-A2 | HYDROXAMATES AS THERAPEUTIC AGENTS | AXYS PHARMACEUTICALS, INC. (US) | 2006-01-04 | — | — | EP | claimed |
| WO-2004092115-A2 | HYDROXAMATES AS THERAPEUTIC AGENTS | AXYS PHARMACEUTICALS INC. (US) | 2004-10-28 | — | — | WO | claimed |