Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NPC1 | O15118 | 7/20 | 0.46 |
| ▸ | RAB9A | P51151 | 6/20 | 0.46 |
| ▸ | SMN1; SMN2 | Q16637 | 5/20 | 0.46 |
| ▸ | PKM | P14618 | 2/20 | 0.46 |
| ▸ | MITF | O75030 | 1/20 | 0.46 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.46 |
| ▸ | LMNA | P02545 | 2/20 | 0.44 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.44 |
| ▸ | MAPT | P10636 | 3/20 | 0.43 |
| ▸ | MEN1 | O00255 | 2/20 | 0.43 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.43 |
| ▸ | HTT | P42858 | 1/20 | 0.43 |
| ▸ | NQO1 | P15559 | 1/20 | 0.42 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.39 |
| ▸ | LTA4H | P09960 | 1/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.38 |
| ▸ | HPGD | P15428 | 2/20 | 0.38 |
| ▸ | TP53 | P04637 | 2/20 | 0.38 |
| ▸ | TSHR | P16473 | 1/20 | 0.37 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5788858 | 0.83 | NPC1 (0.41) | NPC1RAB9ASMN1; SMN2PKMMAPT | |
| SCHEMBL5789228 | 0.76 | NPC1 (0.42) | NPC1RAB9ASMN1; SMN2L3MBTL1LMNA | |
| SCHEMBL5790354 | 0.76 | ALDH1A1 (0.34) | L3MBTL1LMNAALDH1A1TP53MAPK1 | |
| SCHEMBL17536769 | 0.75 | KDM4E (0.44) | NPC1RAB9ASMN1; SMN2L3MBTL1LMNA | |
| SCHEMBL9559546 | 0.75 | NPC1 (0.47) | NPC1RAB9ASMN1; SMN2LMNAMAPT | |
| SCHEMBL15353463 | 0.74 | LMNA (0.37) | NPC1RAB9ASMN1; SMN2PKMMITF | |
| SCHEMBL9559591 | 0.72 | NQO1 (0.39) | NPC1RAB9ASMN1; SMN2NPSR1MAPT | |
| SCHEMBL215577 | 0.71 | ADORA3 (0.43) | NPC1RAB9ASMN1; SMN2PKML3MBTL1 | |
| SCHEMBL5789690 | 0.70 | ALDH1A1 (0.33) | ALDH1A1TSHR | |
| SCHEMBL3735038 | 0.69 | NQO1 (0.50) | NPC1RAB9ASMN1; SMN2PKMLMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1660500-A1 | SUBSTITUTED IMIDAZOPYRIMIDINES FOR THE PREVENTION AND TREATMENT OF CANCER | LABORATORIOS S.A.L.V.A.T., S.A. (ES) | 2006-05-31 | — | — | EP | disclosed |
| WO-2005014598-A1 | SUBSTITUTED IMIDAZOPYRIMIDINES FOR THE PREVENTION AND TREATMENT OF CANCER | LABORATORIOS S.A.L.V.A.T., S.A. (ES) | 2005-02-17 | — | — | WO | disclosed |