SCHEMBL5792891

SCHEMBL5792891

CC1[C@H](C(N)=O)OC(=O)N1c1ccc2c(c1)CCC(=O)N2C

nearest known ligand 0.40

Predicted protein targets (top 13)

geneUniProtsupporting neighboursconfidence
CYP11B2 P19099 13/20 0.40
CYP11B1 P15538 8/20 0.39
CYP1A2 P05177 2/20 0.39
CYP17A1 P05093 1/20 0.39
CYP19A1 P11511 1/20 0.39
PDE3B Q13370 1/20 0.38
PDE3A Q14432 1/20 0.38
BRD4 O60885 1/20 0.36
CREBBP Q92793 1/20 0.36
TRIM24 O15164 2/20 0.35
METAP2 P50579 1/20 0.35
SYK P43405 2/20 0.34
TYRO3 Q06418 1/20 0.34

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL6691654 0.81 MAOA (0.35) CYP11B2CYP11B1
SCHEMBL6686796 0.77 MAOA (0.47) CYP11B2CYP11B1CYP1A2CYP17A1CYP19A1
SCHEMBL3029206 0.77 MAOA (0.47) CYP11B2CYP11B1CYP1A2CYP17A1CYP19A1
SCHEMBL6686228 0.72 TMEM97 (0.33) CYP11B2
SCHEMBL14069523 0.71 PDE3B (0.32) CYP11B2CYP11B1CYP1A2PDE3BPDE3A
SCHEMBL9964724 0.70 CYP11B1 (0.31) CYP11B2CYP11B1CYP1A2CYP17A1CYP19A1
SCHEMBL3029321 0.70 TNF (0.32)
SCHEMBL6672496 0.68 TIPARP (0.38)
SCHEMBL6528456 0.68 F10 (0.50) CYP11B2CYP11B1
SCHEMBL6528455 0.68 F10 (0.50) CYP11B2CYP11B1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-1478629-B1 N-ARYL-2-OXAZOLIDINONE-5-CARBOXAMIDES AND THEIR DERIVATIVES AND THEIR USE AS ANTIBACTERIALS PHARMACIA & UPJOHN CO LLC (US) 2006-10-11 EP claimed
EP-1478629-B1 N-ARYL-2-OXAZOLIDINONE-5-CARBOXAMIDES AND THEIR DERIVATIVES AND THEIR USE AS ANTIBACTERIALS PHARMACIA & UPJOHN CO LLC (US) 2006-10-11 EP disclosed
EP-1478629-A1 N-ARYL-2-OXAZOLIDINONE-5-CARBOXAMIDES AND THEIR DERIVATIVES AND THEIR USE AS ANTIBACTERIALS PHARMACIA & UPJOHN COMPANY (US) 2004-11-24 EP disclosed
WO-2003072553-A1 N-ARYL-2-OXAZOLIDINONE-5-CARBOXAMIDES AND THEIR DERIVATES AND THEIR USE AS ANTIBACTERIALS PHARMACIA & UPJOHN COMPANY (US) 2003-09-04 WO disclosed