Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MEN1 | O00255 | 4/20 | 0.47 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.47 |
| ▸ | DRD2 | P14416 | 1/20 | 0.43 |
| ▸ | LMNA | P02545 | 1/20 | 0.42 |
| ▸ | CCR8 | P51685 | 1/20 | 0.42 |
| ▸ | FAAH | O00519 | 1/20 | 0.41 |
| ▸ | OPRM1 | P35372 | 1/20 | 0.41 |
| ▸ | HTT | P42858 | 1/20 | 0.41 |
| ▸ | POLB | P06746 | 1/20 | 0.40 |
| ▸ | GNAI3 | P08754 | 1/20 | 0.40 |
| ▸ | CHRM2 | P08172 | 1/20 | 0.40 |
| ▸ | CHRM4 | P08173 | 1/20 | 0.40 |
| ▸ | CHRM5 | P08912 | 1/20 | 0.40 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.40 |
| ▸ | CHRM3 | P20309 | 1/20 | 0.40 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL604428 | 0.93 | DRD2 (0.46) | DRD2CCR8FAAHOPRM1KDM4E | |
| SCHEMBL605127 | 0.87 | KDM4E (0.49) | DRD2LMNACCR8FAAHOPRM1 | |
| SCHEMBL604939 | 0.86 | CHRM3 (0.52) | MEN1KMT2AFAAHPOLBGNAI3 | |
| SCHEMBL605914 | 0.85 | DRD2 (0.46) | DRD2CCR8FAAHKDM4EALDH1A1 | |
| SCHEMBL603848 | 0.77 | DRD4 (0.46) | DRD2CHRM2CHRM3ALDH1A1 | |
| SCHEMBL603549 | 0.75 | CARM1 (0.53) | DRD2OPRM1HTTKDM4EALDH1A1 | |
| SCHEMBL603140 | 0.75 | CARM1 (0.53) | MEN1KMT2AALDH1A1 | |
| SCHEMBL5765258 | 0.75 | DRD4 (0.46) | — | |
| SCHEMBL606084 | 0.75 | ACHE (0.51) | MEN1KMT2A | |
| SCHEMBL604129 | 0.75 | ACHE (0.50) | KMT2ADRD2LMNACHRM2CHRM4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1651634-A1 | IMIDAZOL DERIVATIVES OF PIPERIDINE AS HISTAMINE ANTAGONISTS | AstraZeneca AB (SE) | 2006-05-03 | — | — | EP | disclosed |
| WO-2005014579-A1 | IMIDAZOL DERIVATIVES OF PIPERDINE AS HISTAMINE ANTAGONISTS | ASTRAZENECA AB (SE) | 2005-02-17 | — | — | WO | disclosed |