Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CTSS | P25774 | 14/20 | 0.39 |
| ▸ | CTSK | P43235 | 2/20 | 0.39 |
| ▸ | CTSL | P07711 | 1/20 | 0.39 |
| ▸ | CTSB | P07858 | 1/20 | 0.39 |
| ▸ | NPC1 | O15118 | 2/20 | 0.36 |
| ▸ | RAB9A | P51151 | 2/20 | 0.36 |
| ▸ | MEN1 | O00255 | 2/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.36 |
| ▸ | TP53 | P04637 | 1/20 | 0.36 |
| ▸ | GAA | P10253 | 1/20 | 0.36 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.36 |
| ▸ | ESR2 | Q92731 | 1/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.34 |
| ▸ | LMNA | P02545 | 1/20 | 0.34 |
| ▸ | HTT | P42858 | 1/20 | 0.34 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5791415 | 0.89 | CTSK (0.47) | CTSSCTSKCTSLCTSBMEN1 | |
| SCHEMBL8270745 | 0.82 | CTSL (0.59) | CTSSCTSKCTSLCTSBNPC1 | |
| SCHEMBL5794197 | 0.81 | CTSK (0.39) | CTSSCTSKCTSLCTSBGAA | |
| SCHEMBL5793933 | 0.80 | CTSK (0.39) | CTSSCTSKCTSLCTSB | |
| SCHEMBL8270725 | 0.79 | HRH3 (0.47) | CTSSCTSKCTSLCTSBKMT2A | |
| SCHEMBL5792701 | 0.79 | CTSK (0.38) | CTSSCTSKCTSLCTSBRAB9A | |
| SCHEMBL5792705 | 0.78 | CTSK (0.42) | CTSSCTSKCTSLCTSBTP53 | |
| SCHEMBL5791497 | 0.78 | CTSK (0.42) | CTSSCTSKCTSLCTSB | |
| Trifluoroacetic Acid SCHEMBL5791015 | 0.77 | CTSL (0.54) | CTSSCTSKCTSLCTSBNPC1 | |
| SCHEMBL5795001 | 0.77 | FGFR4 (0.38) | CTSSCTSKCTSLCTSB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2006027211-A1 | 2,4-SUBSTITUTED PYRIMIDINES AS CYSTEINE PROTEASE INHIBITORS | GLAXO GROUP LIMITED (GB) | 2006-03-16 | — | — | WO | claimed |
| WO-2006027211-A1 | 2,4-SUBSTITUTED PYRIMIDINES AS CYSTEINE PROTEASE INHIBITORS | GLAXO GROUP LIMITED (GB) | 2006-03-16 | — | — | WO | disclosed |