Predicted protein targets (top 4)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ACHE | P22303 | 10/20 | 0.46 |
| ▸ | MAOA | P21397 | 4/20 | 0.36 |
| ▸ | MAOB | P27338 | 4/20 | 0.36 |
| ▸ | BCHE | P06276 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3300396 | 0.85 | ACHE (0.49) | ACHEMAOAMAOBBCHE | |
| SCHEMBL3299930 | 0.85 | ACHE (0.49) | ACHEMAOAMAOBBCHE | |
| SCHEMBL5790932 | 0.84 | ACHE (0.43) | ACHEMAOAMAOB | |
| SCHEMBL5899449 | 0.84 | ACHE (0.48) | ACHEMAOAMAOBBCHE | |
| SCHEMBL3378411 | 0.81 | MAOA (0.56) | ACHEMAOAMAOBBCHE | |
| SCHEMBL3378409 | 0.81 | MAOA (0.56) | ACHEMAOAMAOBBCHE | |
| SCHEMBL5899576 | 0.80 | ACHE (0.46) | ACHEMAOAMAOB | |
| SCHEMBL3299004 | 0.79 | ACHE (0.56) | ACHEMAOAMAOBBCHE | |
| SCHEMBL12450286 | 0.78 | ACHE (0.41) | ACHEMAOAMAOBBCHE | |
| SCHEMBL3300195 | 0.77 | ACHE (0.58) | ACHEMAOAMAOBBCHE |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2006014968-A2 | PROPARGYL NITROXYDES AND INDANYL NITROXIDES AND THEIR USE FOR THE TREATMENT OF NEUROLOGIC DISEASES AND DISORDERS | TEVA PHARMACEUTICAL INDUSTRIES, LTD. (IL) | 2006-02-09 | — | — | WO | disclosed |
| US-20060025446-A1 | Propargyl nitroxides and indanyl nitroxides and their use for the treatment of neurologic diseases and disorders | TEVA PHARMACEUTICAL INDUSTRIES, LTD. (IL) | 2006-02-02 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20060025446-A1 | Propargyl nitroxides and indanyl nitroxides and their use for the treatment of neurologic diseases and disorders | CBR1, NR1H2, NR1H3 | ACHE 138/4885MAOA 1371/4885MAOB 996/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.