Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 2/20 | 0.35 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.35 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.35 |
| ▸ | MEN1 | O00255 | 2/20 | 0.35 |
| ▸ | IDO1 | P14902 | 4/20 | 0.33 |
| ▸ | HPGD | P15428 | 2/20 | 0.33 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.33 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.33 |
| ▸ | LMNA | P02545 | 2/20 | 0.32 |
| ▸ | TDO2 | P48775 | 1/20 | 0.32 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.32 |
| ▸ | TP53 | P04637 | 1/20 | 0.32 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.32 |
| ▸ | HTT | P42858 | 1/20 | 0.32 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.32 |
| ▸ | HTR6 | P50406 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5797369 | 0.85 | MAPT (0.42) | MAPTKMT2AKDM4EMEN1IDO1 | |
| SCHEMBL5795867 | 0.82 | MAPT (0.39) | MAPTKMT2AKDM4EMEN1IDO1 | |
| SCHEMBL5069977 | 0.78 | RAPGEF4 (0.41) | MAPTKMT2AKDM4EMEN1HPGD | |
| SCHEMBL1748729 | 0.77 | MEN1 (0.34) | MAPTKMT2AKDM4EMEN1HPGD | |
| SCHEMBL5796903 | 0.74 | EGFR (0.40) | MAPTKMT2AKDM4EMEN1HPGD | |
| SCHEMBL5796339 | 0.73 | CTSV (0.41) | MAPTHPGDSMN1; SMN2L3MBTL1LMNA | |
| SCHEMBL5796390 | 0.73 | EGFR (0.39) | MAPTKMT2AKDM4EMEN1HPGD | |
| SCHEMBL5794254 | 0.70 | NPSR1 (0.41) | KMT2AKDM4EMEN1L3MBTL1LMNA | |
| SCHEMBL5069866 | 0.70 | CTSV (0.43) | MAPTKMT2AMEN1HPGDSMN1; SMN2 | |
| SCHEMBL5794825 | 0.70 | CTSV (0.43) | MAPTKMT2AMEN1HPGDSMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1732546-A2 | NOVEL PYRROLO (2,3-B)PYRIDINE DERIVATIVES, THE PREPARATION AND THE PHARMACEUTICAL USE THEREOF IN THE FORM OF KINASE INHIBITORS | Aventis Pharma S.A. (FR) | 2006-12-20 | — | — | EP | disclosed |
| WO-2005095399-A2 | NOVEL PYRROLO (2,3-B)PYRIDINE DERIVATIVES, THE PREPARATION AND THE PHARMACEUTICAL USE THEREOF IN THE FORM OF KINASE INHIBITORS | AVENTIS PHARMA S.A. (FR) | 2005-10-13 | — | — | WO | disclosed |