SCHEMBL5794935

SCHEMBL5794935

Cn1cnc2c(=O)n(-c3ccc(Cl)c(F)c3)c(SCCC(F)(F)F)nc21.Cn1cnc2c(=O)n(-c3ccc(F)cc3)c(SCCC(F)(F)F)nc21

nearest known ligand 0.40

Predicted protein targets (top 15)

geneUniProtsupporting neighboursconfidence
MEN1 O00255 5/20 0.40
KMT2A Q03164 5/20 0.40
ALDH1A3 P47895 4/20 0.36
ALDH1A2 O94788 3/20 0.36
ALDH1A1 P00352 3/20 0.34
MAOA P21397 1/20 0.34
MAOB P27338 1/20 0.34
NPSR1 Q6W5P4 1/20 0.34
GRM1 Q13255 1/20 0.34
TP53 P04637 1/20 0.33
PDE4B Q07343 1/20 0.33
PDE4D Q08499 1/20 0.33
GPBAR1 Q8TDU6 1/20 0.33
MAT2A P31153 1/20 0.33
TRPA1 O75762 1/20 0.32

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL5431789 0.96 GRM1 (0.36) MEN1KMT2AALDH1A3ALDH1A2ALDH1A1
SCHEMBL5438500 0.91 MAOA (0.40) MEN1KMT2AALDH1A3ALDH1A2ALDH1A1
SCHEMBL5446878 0.89 BRD9 (0.39) MEN1KMT2AALDH1A3ALDH1A2ALDH1A1
SCHEMBL5432024 0.88 ALDH1A2 (0.34) MEN1KMT2AALDH1A3ALDH1A2ALDH1A1
SCHEMBL5431688 0.86 MEN1 (0.33) MEN1KMT2AALDH1A3ALDH1A2ALDH1A1
SCHEMBL5431360 0.86 MEN1 (0.35) MEN1KMT2AALDH1A3ALDH1A2ALDH1A1
SCHEMBL5429219 0.86 ALDH1A2 (0.40) KMT2AALDH1A3ALDH1A2MAOAMAOB
SCHEMBL5429779 0.85 TP53 (0.39) MEN1KMT2AALDH1A1NPSR1TP53
SCHEMBL5432062 0.85 BRD9 (0.39) MEN1KMT2AALDH1A3ALDH1A2ALDH1A1
SCHEMBL5427442 0.84 CTSS (0.35) MEN1KMT2AALDH1A3ALDH1A2ALDH1A1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-1687306-A1 BICYCLIC PYRIMIDIN-4-(3H)-ONES AND ANALOGUES AND DERIVATIVES THEREOF WHICH MODULATE THE FUNCTION OF THE VANILLOID-1 RECEPTOR (VR1) MERCK SHARP & DOHME LTD. (GB) 2006-08-09 EP claimed
WO-2005049613-A1 BICYCLIC PYRIMIDIN-4-(3H)-ONES AND ANALOGUES AND DERIVATIVES THEREOF WHICH MODULATE THE FUNCTION OF THE VANILLOID-1 RECEPTOR (VR1) MERCK SHARP & DOHME LIMITED (GB) 2005-06-02 WO claimed