Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CTSK | P43235 | 13/20 | 0.44 |
| ▸ | CTSL | P07711 | 3/20 | 0.44 |
| ▸ | CTSS | P25774 | 3/20 | 0.44 |
| ▸ | CTSB | P07858 | 1/20 | 0.40 |
| ▸ | GPR4 | P46093 | 2/20 | 0.38 |
| ▸ | JAK2 | O60674 | 2/20 | 0.36 |
| ▸ | JAK3 | P52333 | 2/20 | 0.36 |
| ▸ | TBK1 | Q9UHD2 | 2/20 | 0.36 |
| ▸ | IKBKE | Q14164 | 1/20 | 0.36 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5793222 | 0.89 | CTSK (0.41) | CTSKCTSLCTSSCTSBGPR4 | |
| Trifluoroacetic Acid SCHEMBL5795046 | 0.86 | HRH4 (0.41) | CTSKCTSLCTSSCTSB | |
| SCHEMBL8270035 | 0.81 | CTSK (0.51) | CTSKCTSLCTSSCTSBGPR4 | |
| Trifluoroacetic Acid SCHEMBL5794574 | 0.78 | CTSK (0.48) | CTSKCTSLCTSSCTSBGPR4 | |
| Trifluoroacetic Acid SCHEMBL5804566 | 0.78 | CTSK (0.46) | CTSKCTSLCTSSCTSBGPR4 | |
| SCHEMBL8270525 | 0.76 | CTSK (0.63) | CTSKCTSLCTSSCTSBGPR4 | |
| SCHEMBL5529854 | 0.74 | CTSL (0.44) | CTSKCTSLCTSSCTSBJAK2 | |
| SCHEMBL5500170 | 0.74 | CTSK (0.58) | CTSKCTSLCTSSCTSBGPR4 | |
| Trifluoroacetic Acid SCHEMBL5791240 | 0.74 | CTSK (0.57) | CTSKCTSLCTSSCTSBGPR4 | |
| SCHEMBL5522122 | 0.72 | CTSK (0.41) | CTSKCTSLCTSSCTSBTBK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2006027211-A1 | 2,4-SUBSTITUTED PYRIMIDINES AS CYSTEINE PROTEASE INHIBITORS | GLAXO GROUP LIMITED (GB) | 2006-03-16 | — | — | WO | claimed |