Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | OPRM1 | P35372 | 13/20 | 0.58 |
| ▸ | OPRD1 | P41143 | 11/20 | 0.58 |
| ▸ | OPRK1 | P41145 | 8/20 | 0.58 |
| ▸ | LTA4H | P09960 | 1/20 | 0.52 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.52 |
| ▸ | GRIN2D | O15399 | 1/20 | 0.51 |
| ▸ | GRIN3B | O60391 | 1/20 | 0.51 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.51 |
| ▸ | SLC6A3 | Q01959 | 1/20 | 0.51 |
| ▸ | GRIN1 | Q05586 | 1/20 | 0.51 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.51 |
| ▸ | GRIN2A | Q12879 | 1/20 | 0.51 |
| ▸ | GRIN2B | Q13224 | 1/20 | 0.51 |
| ▸ | ROCK1 | Q13464 | 1/20 | 0.51 |
| ▸ | GRIN2C | Q14957 | 1/20 | 0.51 |
| ▸ | GRIN3A | Q8TCU5 | 1/20 | 0.51 |
| ▸ | MEN1 | O00255 | 1/20 | 0.50 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.50 |
| ▸ | ATM | Q13315 | 1/20 | 0.50 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL579506 | 0.90 | OPRM1 (0.76) | OPRM1OPRD1OPRK1LTA4HEPHX2 | |
| SCHEMBL579507 | 0.83 | OPRM1 (0.56) | OPRM1OPRD1OPRK1LTA4HEPHX2 | |
| SCHEMBL579810 | 0.82 | LTA4H (0.68) | OPRM1OPRD1OPRK1LTA4HEPHX2 | |
| SCHEMBL5751520 | 0.76 | OPRM1 (0.58) | OPRM1OPRD1OPRK1GRIN2DGRIN3B | |
| SCHEMBL579849 | 0.76 | OPRM1 (0.53) | OPRM1OPRD1OPRK1LTA4HEPHX2 | |
| SCHEMBL9154589 | 0.76 | LTA4H (0.79) | OPRM1OPRD1OPRK1LTA4HEPHX2 | |
| SCHEMBL9081140 | 0.74 | LTA4H (0.82) | OPRM1OPRD1OPRK1LTA4HEPHX2 | |
| SCHEMBL8499156 | 0.74 | LTA4H (0.82) | OPRM1OPRD1OPRK1LTA4HEPHX2 | |
| SCHEMBL2893629 | 0.74 | GAA (0.74) | OPRM1OPRD1OPRK1LTA4HEPHX2 | |
| SCHEMBL3692341 | 0.74 | OPRM1 (1.00) | OPRM1OPRD1OPRK1LTA4HEPHX2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1735268-B1 | OPIOID RECEPTOR ANTAGONISTS | LILLY CO ELI (US) | 2012-02-15 | — | — | EP | disclosed |