Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.46 |
| ▸ | HTT | P42858 | 3/20 | 0.43 |
| ▸ | LMNA | P02545 | 5/20 | 0.42 |
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.42 |
| ▸ | MAPT | P10636 | 2/20 | 0.42 |
| ▸ | PTGS2 | P35354 | 2/20 | 0.42 |
| ▸ | CYP19A1 | P11511 | 1/20 | 0.42 |
| ▸ | NPC1 | O15118 | 1/20 | 0.40 |
| ▸ | RAB9A | P51151 | 1/20 | 0.40 |
| ▸ | POLB | P06746 | 2/20 | 0.39 |
| ▸ | HPGD | P15428 | 1/20 | 0.39 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.39 |
| ▸ | ERN1 | O75460 | 1/20 | 0.39 |
| ▸ | TLR9 | Q9NR96 | 1/20 | 0.38 |
| ▸ | PKM | P14618 | 1/20 | 0.38 |
| ▸ | MEN1 | O00255 | 2/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5798998 | 0.84 | TDP1 (0.47) | TDP1HTTLMNASMN1; SMN2ALDH1A1 | |
| SCHEMBL5798976 | 0.81 | HTT (0.47) | TDP1HTTLMNASMN1; SMN2ALDH1A1 | |
| SCHEMBL5796814 | 0.81 | HTT (0.47) | TDP1HTTLMNASMN1; SMN2ALDH1A1 | |
| SCHEMBL5798378 | 0.75 | CTSV (0.46) | TDP1HTTLMNASMN1; SMN2ALDH1A1 | |
| SCHEMBL2390951 | 0.74 | ALDH1A1 (0.52) | TDP1HTTLMNASMN1; SMN2ALDH1A1 | |
| Methanesulfonamide SCHEMBL8012477 | 0.70 | CA2 (0.47) | TDP1HTTALDH1A1MAPTPOLB | |
| SCHEMBL1098465 | 0.70 | ERN1 (0.62) | TDP1HTTLMNASMN1; SMN2ALDH1A1 | |
| SCHEMBL31597603 | 0.70 | ERN1 (0.62) | TDP1HTTLMNASMN1; SMN2ALDH1A1 | |
| SCHEMBL5798781 | 0.70 | MEN1 (0.59) | TDP1HTTLMNASMN1; SMN2ALDH1A1 | |
| SCHEMBL3857441 | 0.69 | MEN1 (0.46) | TDP1HTTLMNASMN1; SMN2ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2006040650-A1 | 4-METHOXYACRIDINE-1-CARBOXAMIDE DERIVATIVES AND THE PHENAZINE AND OXANTHRENE ANALOGS AS PDE4-INHIBITORS FOR THE TREATMENT OF ASTHMA AND CHRONIC PULMONARY DISEASE (COPD) | GLENMARK PHARMACEUTICALS S.A. (US) | 2006-04-20 | — | — | WO | disclosed |