Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CA2 | P00918 | 1/20 | 0.37 |
| ▸ | ACHE | P22303 | 1/20 | 0.37 |
| ▸ | EGFR | P00533 | 6/20 | 0.35 |
| ▸ | ERBB2 | P04626 | 5/20 | 0.35 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.33 |
| ▸ | HIF1A | Q16665 | 2/20 | 0.33 |
| ▸ | TP53 | P04637 | 1/20 | 0.33 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.33 |
| ▸ | TSHR | P16473 | 1/20 | 0.33 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.33 |
| ▸ | GABRA1 | P14867 | 1/20 | 0.32 |
| ▸ | GABRB2 | P47870 | 1/20 | 0.32 |
| ▸ | GLA | P06280 | 1/20 | 0.32 |
| ▸ | ADRA2A | P08913 | 2/20 | 0.31 |
| ▸ | ADRA2B | P18089 | 2/20 | 0.31 |
| ▸ | ADRA2C | P18825 | 2/20 | 0.31 |
| ▸ | ADRA1D | P25100 | 2/20 | 0.31 |
| ▸ | HTR2C | P28335 | 2/20 | 0.31 |
| ▸ | ADRA1A | P35348 | 2/20 | 0.31 |
| ▸ | ADRA1B | P35368 | 2/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5437476 | 0.87 | GABRA1 (0.43) | ALDH1A1HIF1ATP53CYP3A4TSHR | |
| SCHEMBL29148064 | 0.81 | TAAR1 (0.42) | ALDH1A1TSHRGLAHTR2CCYP2A13 | |
| SCHEMBL8976185 | 0.80 | ALDH1A1 (0.46) | CA2EGFRERBB2ALDH1A1HIF1A | |
| SCHEMBL13116361 | 0.79 | HSP90AA1 (0.45) | ACHEEGFRERBB2ALDH1A1HIF1A | |
| SCHEMBL19112118 | 0.78 | ATM (0.41) | CA2ACHEEGFRERBB2HIF1A | |
| SCHEMBL3681261 | 0.75 | TSHR (0.44) | ALDH1A1HIF1ATP53CYP3A4TSHR | |
| SCHEMBL23628577 | 0.75 | HMGB1 (0.53) | CA2ALDH1A1CYP3A4SMN1; SMN2 | |
| SCHEMBL8220623 | 0.75 | ALDH1A1 (0.54) | ALDH1A1HIF1ATP53CYP3A4TSHR | |
| SCHEMBL4959653 | 0.75 | ALDH1A1 (0.54) | ALDH1A1HIF1ATP53CYP3A4TSHR | |
| SCHEMBL29826970 | 0.74 | TDP1 (0.45) | ALDH1A1HIF1ATP53CYP3A4TSHR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7470799-B2 | Dihydrobenzofuran derivatives and uses thereof | WYETH (US) | 2008-12-30 | — | — | US | disclosed |
| US-7470799-B2 | Dihydrobenzofuran derivatives and uses thereof | WYETH (US) | 2008-12-30 | — | — | US | disclosed |
| WO-2006000902-A1 | DIHYDROBENZOFURAN COMPOUNDS AND USES THEREOF | PFIZER PRODUCTS INC. (US) | 2006-01-05 | — | — | WO | disclosed |