SCHEMBL5795451

SCHEMBL5795451

NC(=O)C1CN(c2ccc3c(c2)CCN(C(=O)CO)CC3)C(=O)O1

nearest known ligand 0.46

Predicted protein targets (top 5)

geneUniProtsupporting neighboursconfidence
MAOA P21397 3/20 0.46
HTR6 P50406 7/20 0.41
F10 P00742 1/20 0.39
MAOB P27338 1/20 0.35
CALML3 P27482 1/20 0.33

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL3043362 1.00 MAOA (0.46) MAOAHTR6F10MAOBCALML3
SCHEMBL6694779 0.87 MAOA (0.43) MAOAHTR6F10
SCHEMBL3046390 0.87 F10 (0.39) MAOAHTR6F10MAOB
SCHEMBL3043072 0.87 MAOA (0.43) MAOAHTR6F10
SCHEMBL3035135 0.82 MAOA (0.47) MAOAHTR6
SCHEMBL14334647 0.80 HTR6 (0.62) MAOAHTR6MAOB
SCHEMBL6040285 0.79 MAOA (0.55) MAOAF10MAOBCALML3
SCHEMBL3039174 0.79 F10 (0.61) MAOAF10MAOBCALML3
SCHEMBL6040445 0.78 F10 (0.51) MAOAF10MAOBCALML3
SCHEMBL6764236 0.78 F10 (0.51) MAOAF10MAOBCALML3

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-1478629-B1 N-ARYL-2-OXAZOLIDINONE-5-CARBOXAMIDES AND THEIR DERIVATIVES AND THEIR USE AS ANTIBACTERIALS PHARMACIA & UPJOHN CO LLC (US) 2006-10-11 EP disclosed
EP-1478629-A1 N-ARYL-2-OXAZOLIDINONE-5-CARBOXAMIDES AND THEIR DERIVATIVES AND THEIR USE AS ANTIBACTERIALS PHARMACIA & UPJOHN COMPANY (US) 2004-11-24 EP disclosed
WO-2003072553-A1 N-ARYL-2-OXAZOLIDINONE-5-CARBOXAMIDES AND THEIR DERIVATES AND THEIR USE AS ANTIBACTERIALS PHARMACIA & UPJOHN COMPANY (US) 2003-09-04 WO disclosed