Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HSD11B1 | P28845 | 1/20 | 0.61 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.50 |
| ▸ | MEN1 | O00255 | 6/20 | 0.49 |
| ▸ | KMT2A | Q03164 | 6/20 | 0.49 |
| ▸ | AKR1C3 | P42330 | 1/20 | 0.49 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.47 |
| ▸ | HTT | P42858 | 1/20 | 0.47 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.47 |
| ▸ | LMNA | P02545 | 2/20 | 0.47 |
| ▸ | GAA | P10253 | 1/20 | 0.47 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.47 |
| ▸ | HDAC4 | P56524 | 1/20 | 0.47 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.47 |
| ▸ | HDAC7 | Q8WUI4 | 1/20 | 0.47 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.47 |
| ▸ | HDAC10 | Q969S8 | 1/20 | 0.47 |
| ▸ | HDAC11 | Q96DB2 | 1/20 | 0.47 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.47 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.47 |
| ▸ | HDAC9 | Q9UKV0 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3926479 | 0.85 | HSD11B1 (0.61) | HSD11B1ALDH1A1MEN1KMT2AHTT | |
| SCHEMBL5797968 | 0.84 | KMT2A (0.68) | HSD11B1ALDH1A1MEN1KMT2ASMN1; SMN2 | |
| SCHEMBL5794917 | 0.82 | HDAC3 (0.51) | ALDH1A1MEN1KMT2AHTTLMNA | |
| SCHEMBL3926842 | 0.79 | HSD11B1 (0.62) | HSD11B1MEN1KMT2A | |
| SCHEMBL3618451 | 0.78 | KMT2A (0.73) | ALDH1A1MEN1KMT2ASMN1; SMN2HTT | |
| SCHEMBL5794925 | 0.77 | MCL1 (0.48) | HSD11B1ALDH1A1HDAC1MCL1 | |
| SCHEMBL9927453 | 0.76 | HSD11B1 (1.00) | HSD11B1ALDH1A1MEN1KMT2ALMNA | |
| SCHEMBL13485906 | 0.73 | HSD11B1 (0.61) | HSD11B1ALDH1A1MEN1KMT2AAKR1C3 | |
| SCHEMBL21392233 | 0.71 | CTPS1 (0.64) | — | |
| SCHEMBL6438335 | 0.71 | ALDH1A1 (0.69) | ALDH1A1KMT2AGAATDP1KAT6A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2006050908-A1 | INHIBITORS OF 11ΒΕΤΑ-HYDROXY STEROID DEHYDROGENASE TYPE 1 (11BETA-HSD1) | EVOTEC AG (DE) | 2006-05-18 | — | — | WO | disclosed |