Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KMT2A | Q03164 | 7/20 | 0.68 |
| ▸ | MEN1 | O00255 | 6/20 | 0.68 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.68 |
| ▸ | HSD11B1 | P28845 | 2/20 | 0.60 |
| ▸ | GAA | P10253 | 2/20 | 0.54 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.51 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.51 |
| ▸ | PKM | P14618 | 1/20 | 0.48 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.47 |
| ▸ | MAPT | P10636 | 1/20 | 0.46 |
| ▸ | KAT6A | Q92794 | 1/20 | 0.45 |
| ▸ | LMNA | P02545 | 1/20 | 0.45 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.45 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.45 |
| ▸ | HDAC4 | P56524 | 1/20 | 0.45 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.45 |
| ▸ | HDAC7 | Q8WUI4 | 1/20 | 0.45 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.45 |
| ▸ | HDAC10 | Q969S8 | 1/20 | 0.45 |
| ▸ | HDAC11 | Q96DB2 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5798138 | 0.87 | ALDH1A1 (0.53) | KMT2AMEN1ALDH1A1HSD11B1CYP2C9 | |
| SCHEMBL5794528 | 0.86 | PKM (0.53) | KMT2AMEN1ALDH1A1HSD11B1GAA | |
| SCHEMBL5796067 | 0.84 | HSD11B1 (0.61) | KMT2AMEN1ALDH1A1HSD11B1GAA | |
| SCHEMBL5811010 | 0.82 | KMT2A (0.61) | KMT2AMEN1ALDH1A1HSD11B1CYP2C9 | |
| SCHEMBL5806893 | 0.80 | CDK5 (0.49) | KMT2AMEN1ALDH1A1HSD11B1CYP2C9 | |
| SCHEMBL5794952 | 0.78 | HSD11B1 (0.53) | KMT2AMEN1ALDH1A1HSD11B1GAA | |
| SCHEMBL5693072 | 0.76 | HSD11B1 (0.76) | KMT2AMEN1ALDH1A1HSD11B1CYP2C9 | |
| SCHEMBL9927453 | 0.76 | HSD11B1 (1.00) | KMT2AMEN1ALDH1A1HSD11B1PKM | |
| SCHEMBL10420167 | 0.75 | GAA (0.65) | KMT2AMEN1ALDH1A1GAAPKM | |
| SCHEMBL21381652 | 0.75 | CTPS1 (0.57) | KMT2AMEN1ALDH1A1HSD11B1CYP2C9 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2006050908-A1 | INHIBITORS OF 11ΒΕΤΑ-HYDROXY STEROID DEHYDROGENASE TYPE 1 (11BETA-HSD1) | EVOTEC AG (DE) | 2006-05-18 | — | — | WO | disclosed |